Reactions of connective tissue to self-etching/priming dentin bonding systems: oxidative stress, tumor necrosis factor a expression, and tissue reactions

Basit Öğe Kaydı
dc.contributor.authorZorba, Yahya Orçun
dc.contributor.authorYıldız, Mehmet
dc.contributor.authorYıldırım, Abdulkadir
dc.contributor.authorGürsan, Nesrin
dc.contributor.authorErcan, Ertuğrul
dc.date.accessioned2020-06-25T17:48:17Z
dc.date.available2020-06-25T17:48:17Z
dc.date.issued2009
dc.departmentKırıkkale Üniversitesi
dc.descriptionERCAN, Ertugrul/0000-0002-4753-6553
dc.description.abstractBackground/purpose: Few data have been published concerning tissue and systemic responses to resinous dental materials. The aim of this study was to compare and evaluate the biocompatibility of four kinds of dental self-etching/priming adhesives by measuring tissue responses, local and systemic tumor necrosis factor (TNF) alpha expression, and oxidative stress parameters. Materials and methods: Eighty rats were equally divided into 10 groups. Four dental adhesives (Clearfil SE Bond, iBond, Clearfil Protect Bond, and Adper Prompt L-Pop) were applied to connective tissue of the rats. In the control group, rats were operated on with no material being applied. Biocompatibilities of the bonding agents were evaluated according to tissue responses, histopathologic and biochemical TNF-alpha expressions, and levels of malondialdehyde, glutathione, superoxide dismutase and glutathione peroxidase activities 1 week and 1 month after initiation of treatment. Results: All neutrophil levels and edema formation between the iBond group and the other groups were statistically significant after 1 week. Fibroblast levels in the Clearfil SE Bond group were higher than all other groups. Vascularization levels statistically differed between the Clearfil SE Bond and iBond groups, and between the Adper Prompt L-Pop and control groups. Tissue TNF-alpha levels statistically differed in all groups other than the control group. At the end of 1 month, the neutrophil level in the iBond group was higher than that in the control group. The differences in fibroblast levels after 1 month were statistically significant between the Clearfil SE Bond and Clearfil Protect Bond groups, and between the control and iBond groups. Tissue TNF-alpha levels were higher in the iBond, Clearfil Protect Bond, and Adper Prompt L-Pop groups than in the Clearfil SE Bond and control groups. Conclusion: There were no statistical differences in levels of serum TNF-alpha and oxidative stress parameters in any groups during the course of the study. The four different adhesive systems exhibited different degrees of local toxicity to the subsurface of the skin of rats, but no systemic toxicity was detected.en_US
dc.description.sponsorshipAtaturk University Scientific Project Research Foundation, TurkeyAtaturk University [2003166]; Heraeus Kulzer GmbH; Dental Department of Kuraray America, Incen_US
dc.description.sponsorshipThis study was supported by a grant-in-aid (2003166) from the Ataturk University Scientific Project Research Foundation, Turkey. The iBond and Clearfil Protect Bond used in this study was generously supplied by Heraeus Kulzer GmbH and the Dental Department of Kuraray America, Inc. We thank Dr Yunus Emre Ozkanlar for critically reviewing the manuscript.en_US
dc.identifier.citationZorba, Y.O., Yildiz, M.S., Yıldırım, A., Gürsan, N., & Ercan, E. (2009). Reactions of connective tissue to self-etching/priming dentin bonding systems: oxidative stress, tumor necrosis factor α expression, and tissue reactions. Journal of Dental Sciences, 4(3), 136-148.en_US
dc.identifier.doi10.1016/S1991-7902(09)60019-2
dc.identifier.endpage148en_US
dc.identifier.issn1991-7902
dc.identifier.issn2213-8862
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-70350290265
dc.identifier.scopusqualityQ1
dc.identifier.startpage136en_US
dc.identifier.urihttps://doi.org/10.1016/S1991-7902(09)60019-2
dc.identifier.urihttps://hdl.handle.net/20.500.12587/4389
dc.identifier.volume4en_US
dc.identifier.wosWOS:000270695000005
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherElsevier Taiwanen_US
dc.relation.ispartofJournal Of Dental Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectbiocompatibilityen_US
dc.subjectcytokinesen_US
dc.subjectdentin bonding agentsen_US
dc.subjectimmune responseen_US
dc.subjectsoft tissueen_US
dc.titleReactions of connective tissue to self-etching/priming dentin bonding systems: oxidative stress, tumor necrosis factor a expression, and tissue reactionsen_US
dc.typeArticle

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim
İsim:
Reactions of connective tissue to self-etching priming dentin bonding systems oxidative stress, tumor necrosis factor a expression, and tissue reactions.pdf
Boyut:
3.18 MB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin/Full Text
İndir

Koleksiyon

WOS İndeksli Yayınlar Koleksiyonu
Makale Koleksiyonu
Makale Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu