The lethality, histological, haematological and biochemical alterations in mice envenomated with Aegaeobuthus nigrocinctus venom

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dc.authoridBAKIR, FATIH/0000-0002-2281-1694
dc.contributor.authorBakir, Fatih
dc.contributor.authorOzkan, Ozcan
dc.contributor.authorAlcigir, Mehmet Eray
dc.contributor.authorYagmur, Ersen Aydin
dc.date.accessioned2025-01-21T16:45:42Z
dc.date.available2025-01-21T16:45:42Z
dc.date.issued2021
dc.departmentKırıkkale Üniversitesi
dc.description.abstractThere is currently no data regarding the toxicity or the in vivo effects of the venom the Aegaeobuthus nigrocinctus species, since it has not been studied thus far according to the best of our knowledge. In the present study, and for the first time, the median lethal dose, the in vivo toxic effects, the histological changes in some of the vital organs were all determined as well as an assessment was made of the histological, biochemical and haematological changes which were caused by the venom injected in mice. The median lethal dose (LD50) of the scorpion venom for mice was found to be 0.38 mg/kg in terms of body weight. The results of the study show that the A. nigrocintus is a potentially lethal scorpion. The evidence related to the venom indicated that it could cause tissue injury in some vital organs. In conclusion, this scorpion venom could cause significant medical complications, and may lead to death, regarding at-risk patients. Therefore, health professionals should be aware of the various scorpion species in their regions and should follow current medical approaches concerning scorpion envenomation.
dc.identifier.doi10.1016/j.toxicon.2021.07.010
dc.identifier.endpage126
dc.identifier.issn0041-0101
dc.identifier.issn1879-3150
dc.identifier.pmid34302854
dc.identifier.scopus2-s2.0-85111001310
dc.identifier.scopusqualityQ2
dc.identifier.startpage118
dc.identifier.urihttps://doi.org/10.1016/j.toxicon.2021.07.010
dc.identifier.urihttps://hdl.handle.net/20.500.12587/25698
dc.identifier.volume200
dc.identifier.wosWOS:000691778400003
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherPergamon-Elsevier Science Ltd
dc.relation.ispartofToxicon
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241229
dc.subjectAegaeobuthus nigrocinctus Venom; Lethality; Biochemical; Haematological; Histopathology
dc.titleThe lethality, histological, haematological and biochemical alterations in mice envenomated with Aegaeobuthus nigrocinctus venom
dc.typeArticle

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