Effect of Systemic Oxytocin Administration on New Bone Formation and Distraction Rate in Rabbit Mandible

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dc.contributor.authorAltay, Berkan
dc.contributor.authorDede, Eda Ciftci
dc.contributor.authorOzgul, Ozkan
dc.contributor.authorAtil, Fethi
dc.contributor.authorKocyigit, Ismail Doruk
dc.contributor.authorOrhan, Kaan
dc.contributor.authorTekin, Umut
dc.date.accessioned2021-01-14T18:10:32Z
dc.date.available2021-01-14T18:10:32Z
dc.date.issued2020
dc.departmentKKÜ
dc.descriptionOnder, M Ercument/0000-0002-1488-616X; Altay, Berkan/0000-0003-0297-6501; Orhan, Kaan/0000-0001-6768-0176
dc.description.abstractPurpose: The main disadvantage of distraction osteogenesis is the prolonged treatment protocol. Recently, oxytocin (OT) has been found to have anabolic effects on bone metabolism. In this experimental study, the effects of OT on the mandibular distraction gap in rabbits at 2 different distraction rates were evaluated. Materials and Methods: This experimental study was conducted on 28 male New Zealand white rabbits. The animals were divided into 3 experimental groups and 1 control group. Group A (control group, n = 7) consisted of animals with distraction at a rate of 1 mm/day, and group B (n = 7) consisted of animals with a distraction rate of 2 mm/day; groups A and B received postoperative saline solution injection. Group C (n = 7) consisted of animals with distraction at a rate of 1 mm/day, and group D (n = 7) consisted of animals with a distraction rate of 2 mm/day; postoperative OT injection was performed in groups C and D. Results: Both histomorphologic and micro-computed tomography evaluations showed increased bone healing in the OT-treated groups. Conclusions: On the basis of the evaluation of both the histomorphometric and micro-computed tomographic data, systemic OT administration was found to increase new bone formation and bone healing with distraction osteogenesis. (C) 2020 American Association of Oral and Maxillofacial Surgeonsen_US
dc.description.sponsorshipScientific Research Projects Coordination Unit of Kirikkale UniversityKirikkale University [2018/13]en_US
dc.description.sponsorshipThis work was supported by the Scientific Research Projects Coordination Unit of Kirikkale University. Project number 2018/13.en_US
dc.identifier.citationBu makale açık erişimli değildir.en_US
dc.identifier.doi10.1016/j.joms.2020.03.005
dc.identifier.endpage1182en_US
dc.identifier.issn0278-2391
dc.identifier.issn1531-5053
dc.identifier.issue7en_US
dc.identifier.pmid32275899
dc.identifier.scopus2-s2.0-85083562521
dc.identifier.scopusqualityQ1
dc.identifier.startpage1171en_US
dc.identifier.urihttps://doi.org/10.1016/j.joms.2020.03.005
dc.identifier.urihttps://hdl.handle.net/20.500.12587/12659
dc.identifier.volume78en_US
dc.identifier.wosWOS:000545324000029
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherW B SAUNDERS CO-ELSEVIER INCen_US
dc.relation.ispartofJOURNAL OF ORAL AND MAXILLOFACIAL SURGERY
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.titleEffect of Systemic Oxytocin Administration on New Bone Formation and Distraction Rate in Rabbit Mandibleen_US
dc.typeArticle

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