In-vitro studies of enteric coated diclofenac sodium-carboxymethylcellulose microspheres

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dc.contributor.authorArica, B
dc.contributor.authorArica, MY
dc.contributor.authorKas, HS
dc.contributor.authorHincal, AA
dc.contributor.authorHasirci, V
dc.date.accessioned2020-06-25T17:34:34Z
dc.date.available2020-06-25T17:34:34Z
dc.date.issued1996
dc.departmentKırıkkale Üniversitesi
dc.description10th International Symposium on Microencapsulation -- SEP, 1995 -- AUSTIN, TX
dc.description.abstractMicrospheres containing diclofenac sodium (DS) were prepared using carboxymethylcellulose (CMC) as the main support material (1.0, 2.0, 3.0% (w/v)) and aluminium chloride as the crosslinker. Drug to polymer ratios of 1:1, 1:2 and 1:4 were used to obtain a range of microspheres. The microspheres were then coated with an enteric coating material, Eudragit(R)S-100, with aqueous solution concentrations of 10 and 20% (w/v). Encapsulation efficiency, % yield value, particle sizes and in-vitro dissolution behaviour were investigated. The surface of the enteric coated microspheres seemed to be all covered with Eudragit(R)S-100 from scanning electron microscopy observation. It was also observed that increasing the CMC concentration led to an increase in the encapsulation efficiency, % yield value and particle size and decreased the release rate. Eudragit(R)S-100 coating did not significantly alter the size but the release rate was significantly lower even when the lower concentration solution was used.en_US
dc.description.sponsorshipInt Microencapsulat Socen_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.3109/02652049609026052
dc.identifier.endpage699en_US
dc.identifier.issn0265-2048
dc.identifier.issue6en_US
dc.identifier.pmid8933354
dc.identifier.scopus2-s2.0-0029854024
dc.identifier.scopusqualityQ2
dc.identifier.startpage689en_US
dc.identifier.urihttps://doi.org/10.3109/02652049609026052
dc.identifier.urihttps://hdl.handle.net/20.500.12587/2767
dc.identifier.volume13en_US
dc.identifier.wosWOS:A1996VR22200006
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofJournal Of Microencapsulation
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectdiclofenac sodiumen_US
dc.subjectcarboxymethylcellulose microspheresen_US
dc.subjectsustained release drug deliveryen_US
dc.subjectenteric coatingen_US
dc.titleIn-vitro studies of enteric coated diclofenac sodium-carboxymethylcellulose microspheresen_US
dc.typeArticle

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