JAK/STAT pathway modulation: Does it work in dermatology?

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dc.contributor.authorGündüz, Özgür
dc.date.accessioned2020-06-25T18:34:06Z
dc.date.available2020-06-25T18:34:06Z
dc.date.issued2019
dc.departmentKırıkkale Üniversitesi
dc.descriptionGunduz, Ozgur/0000-0003-1021-5219
dc.description.abstractJanus kinase-signal transducer and activator of transcription (JAK/STAT)-is an intracellular signaling pathway, which plays a key role in downstream transmission of extracellular signals from cell membrane to the cell nucleus. This pathway is activated by cytokines, which participate in inflammation, innate and acquired immune responses, and also cell growth. Recent studies point out possible disturbances in JAK/STAT pathway in various inflammatory and autoimmune skin diseases, such as atopic dermatitis, psoriasis, alopecia areata. Several molecules that modulate-inhibit-this pathway are currently under investigation for the evaluation of their clinical use in dermatological diseases. A brief overview of the therapeutical use of JAK/STAT inhibitors in dermatology will be provided here.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1111/dth.12903
dc.identifier.issn1396-0296
dc.identifier.issn1529-8019
dc.identifier.issue3en_US
dc.identifier.pmid30964573
dc.identifier.scopus2-s2.0-85064945543
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1111/dth.12903
dc.identifier.urihttps://hdl.handle.net/20.500.12587/7793
dc.identifier.volume32en_US
dc.identifier.wosWOS:000471833800022
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWileyen_US
dc.relation.ispartofDermatologic Therapy
dc.relation.publicationcategoryDiğeren_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectalopecia areataen_US
dc.subjectanitinflammatoryen_US
dc.subjectatopic dermatitisen_US
dc.subjectimmunomodulationen_US
dc.subjectJakinibsen_US
dc.subjectJanus kinase (JAK)en_US
dc.subjectpsoriasisen_US
dc.subjectsignal transducer and activator of transcription (STAT)en_US
dc.titleJAK/STAT pathway modulation: Does it work in dermatology?en_US
dc.typeLetter

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