Transcriptome analysis and potential mechanisms of bovine oocytes under seasonal heat stress

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dc.authoridKaraman, Kardelen/0000-0002-4201-2363
dc.authoridOzmen, Ozge/0000-0002-8577-7323
dc.contributor.authorOzmen, Ozge
dc.contributor.authorKaraman, Kardelen
dc.date.accessioned2025-01-21T16:55:42Z
dc.date.available2025-01-21T16:55:42Z
dc.date.issued2023
dc.departmentKırıkkale Üniversitesi
dc.description.abstractHeat stress is the major factor affecting cattle fertility but molecular mechanisms of deleterious impacts of elevated temperature on oocyte are still not well known. Therefore, the aim of this study is to gain a better understanding of the underlying molecular mechanism of how heat stress affects GV-stage and MII-stage oocytes and discover hub genes to heat resistance for cow oocytes. In this study, we used the bioinformatics approach to discover the differentially expressed genes between GV-stage and MII-stage oocytes, which were collected during spring and summer. When GV-stage oocytes were compared to MII-stage oocytes collected in July (Jul DEGs group) a total of 1068 genes were found as differentially expressed as a result of heat stress. Also, HSPA8, COPS5, POLR2L, PSMC6, and TPI1 were identified as the common top ranked genes for the Jul DEGs group. The highest connected hub gene for the Jul DEGs group was determined as HSPA8. Our results showed that different heat response mechanisms might be activated to protect oocytes from elevated temperatures in cattle. The identified genes and their associated pathways might play an important role in the response to heat stress that affects the oocytes in cattle.
dc.description.sponsorshipCouncil of Higher Education of Turkey
dc.description.sponsorshipOne of the authors, Kardelen Karaman, would like to thank the Council of Higher Education of Turkey for 100/2000 CoHE Doctoral Scholarship.
dc.identifier.doi10.1080/10495398.2021.2016429
dc.identifier.endpage1195
dc.identifier.issn1049-5398
dc.identifier.issn1532-2378
dc.identifier.issue4
dc.identifier.pmid34928777
dc.identifier.scopus2-s2.0-85121665857
dc.identifier.scopusqualityQ2
dc.identifier.startpage1179
dc.identifier.urihttps://doi.org/10.1080/10495398.2021.2016429
dc.identifier.urihttps://hdl.handle.net/20.500.12587/25806
dc.identifier.volume34
dc.identifier.wosWOS:000734244000001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTaylor & Francis Inc
dc.relation.ispartofAnimal Biotechnology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241229
dc.subjectHeat stress; cows; oocyte; fertility; bioinformatics analysis
dc.titleTranscriptome analysis and potential mechanisms of bovine oocytes under seasonal heat stress
dc.typeArticle

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