Effect of region of interest on interobserver variance in apparent diffusion coefficient measures

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dc.contributor.authorBilgili, Y
dc.contributor.authorUnal, B
dc.date.accessioned2020-06-25T17:40:12Z
dc.date.available2020-06-25T17:40:12Z
dc.date.issued2004
dc.departmentKırıkkale Üniversitesi
dc.descriptionEuropean Congress of Radiology -- MAR 07-11, 2003 -- VIENNA, AUSTRIA
dc.description.abstractBACKGROUND AND PURPOSE: Apparent diffusion coefficient (ADC) values derived from diffusion-weighted MR imaging are useful measurements for assessment of cellular alterations in pathologic conditions of the brain. In this study, two radiologists independently quantitated ADCs and region-of interest sizes in prespecified locations of human brain to test interobserver ADC variance and the effect of varying ROI sizes on ADC differences. METHODS: Twenty-seven patients with normal MR findings underwent diffusion-weighted imaging (b value = 1000 s/mm(2)) on a 1.5-T system. Two radiologists independently placed two ROI areas of 22 +/- 5 mm(2) and 62 +/- 6 mm(2) (former area inside the latter area) at different sites of the brain (centrum semiovale, frontal white matter, nucleus caudatus, putamen, thalamus, substantia nigra, red nucleus, and pons) from trace images. Differences in ADC measurement obtained from each region of the brain for each radiologist and the size of each ROI were compared statistically. RESULTS: Mean ADC of prespecified areas of brain ranged between 0.673 and 0.818 mm(2)/s x 10(-3). Interobserver variance was significant in some of the specified areas (centrum semiovale, frontal white matter, pons, substantia nigra, and red nucleus). Varying ROI sizes at the pons, substantia nigra, and red nucleus yielded statistically different ADC values. CONCLUSION. ADC values are found to be unreliable for use in assessing brain disease in some specified areas of the brain owing to interobserver variance and different ROI sizes.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.endpage111en_US
dc.identifier.issn0195-6108
dc.identifier.issue1en_US
dc.identifier.pmid14729538
dc.identifier.scopus2-s2.0-1642500830
dc.identifier.scopusqualityQ1
dc.identifier.startpage108en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12587/3339
dc.identifier.volume25en_US
dc.identifier.wosWOS:000188763200022
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherAmer Soc Neuroradiologyen_US
dc.relation.ispartofAmerican Journal Of Neuroradiology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.titleEffect of region of interest on interobserver variance in apparent diffusion coefficient measuresen_US
dc.typeArticle

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