The effect of endothelin receptor antagonists in the endotoxin-induced uveitis rabbit model

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dc.contributor.authorKaraca, Emine Esra
dc.contributor.authorUzun, Feyzahan
dc.contributor.authorDilekoz, Ergin
dc.contributor.authorFincan, Gokce Sevim Ozturk
dc.contributor.authorErcan, Sevim
dc.contributor.authorKul, Oguz
dc.contributor.authorOr, Meral
dc.date.accessioned2020-06-25T18:30:07Z
dc.date.available2020-06-25T18:30:07Z
dc.date.issued2018
dc.departmentKırıkkale Üniversitesi
dc.descriptionUzun, Feyzahan/0000-0002-3050-0714
dc.description.abstractPurpose: To investigate the effect of Bosentan (non-selective endothelin receptor antagonist) and BQ123 (ETA receptor antagonist) on intraocular inflammation in an endotoxin-induced uveitis (EIU) rabbit model.Methods: Uveitis was induced by intravitreal injection of lipopolysaccharide (LPS). The animals were divided into 7 groups and there were six rabbits in each group (saline, saline and ethanol, bosentan, BQ123, lipopolysaccharide (LPS), bosentan and LPS, BQ123 and LPS-injected groups). Bosentan and BQ123 were applied before LPS injection. Aqueous humour was collected at 24th hour post-injections and enucleation was performed for the evaluation of histopathological changes.Results: BQ123 decreased clinical score, cell counts and protein amount more than bosentan and it was significant for cell counts (p=0.018). Bosentan significantly diminished inflammatory reactions more than BQ123 as shown in histopathological specimens (p=0.002).Conclusions: ETA receptor blockage is effective on uveitis treatment by its protective effect on blood aqueous barrier.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1080/15569527.2017.1355317
dc.identifier.endpage138en_US
dc.identifier.issn1556-9527
dc.identifier.issn1556-9535
dc.identifier.issue2en_US
dc.identifier.pmid28707522
dc.identifier.scopus2-s2.0-85031402489
dc.identifier.scopusqualityQ3
dc.identifier.startpage133en_US
dc.identifier.urihttps://doi.org/10.1080/15569527.2017.1355317
dc.identifier.urihttps://hdl.handle.net/20.500.12587/7563
dc.identifier.volume37en_US
dc.identifier.wosWOS:000429276400005
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofCutaneous And Ocular Toxicology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectUveitisen_US
dc.subjectlipopolysaccharidesen_US
dc.subjectendothelin receptorsen_US
dc.subjectendothelinen_US
dc.titleThe effect of endothelin receptor antagonists in the endotoxin-induced uveitis rabbit modelen_US
dc.typeArticle

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