Pro12Ala polymorphism of the peroxisome proliferator-activated receptor-gamma gene in women with polycystic ovary syndrome

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dc.contributor.authorYilmaz, Murat
dc.contributor.authorErgün, Mehmet Ali
dc.contributor.authorKarakoc, Ayhan
dc.contributor.authorYurtcu, Erkan
dc.contributor.authorCakir, Nuri
dc.contributor.authorArslan, Metin
dc.date.accessioned2020-06-25T17:43:32Z
dc.date.available2020-06-25T17:43:32Z
dc.date.issued2006
dc.descriptionergun, mehmet ali/0000-0001-9696-0433
dc.description.abstractAim. The present study was designed to examine the relationship between Pro12Ala polymorphism of the peroxisome proliferator-activated receptor-gamma gene (PPAR-gamma) and clinical and hormonal characteristics in women with polycystic ovary syndrome (PCOS). Materials and methods. One hundred patients with PCOS and 100 healthy subjects were included in the study. Serum levels of sex steroids were measured. Insulin resistance was evaluated by homeostasis model assessment (HOMA). The responses of glucose and insulin to an oral glucose tolerance test were analyzed by calculating the respective area under the curve (AUC) by the trapezoidal method. We used the restriction fragment length polymorphism technique and polymerase chain reaction to examine Pro12Ala polymorphism in exon 2 of PPAR-gamma. Results. Pro12Ala polymorphism of PPAR-gamma was significantly elevated in control subjects (22%) compared with PCOS subjects (15%). All of the Pro12Ala polymorphisms of PPAR-gamma were heterozygous. When PCOS subjects with the Pro allele and the Ala allele of PPAR-gamma were compared, the latter had lower free testosterone, androstenedione, dehydroepiandrosterone sulfate, insulin and C-peptide levels, as well as lower luteinizing hormone/follicle-stimulating hormone ratio, HOMA insulin resistance index, AUC(insulin), Ferriman-Gallwey score, acne, body mass index and waist-to-hip ratio. Conclusion. We suggest that Pro12Ala polymorphism of the PPAR-gamma gene maybe a modifier of insulin resistance in women with PCOS.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1080/09513590600733357
dc.identifier.endpage342en_US
dc.identifier.issn0951-3590
dc.identifier.issn1473-0766
dc.identifier.issue6en_US
dc.identifier.pmid16785159
dc.identifier.scopus2-s2.0-33745366449
dc.identifier.scopusqualityQ2
dc.identifier.startpage336en_US
dc.identifier.urihttps://doi.org10.1080/09513590600733357
dc.identifier.urihttps://hdl.handle.net/20.500.12587/3777
dc.identifier.volume22en_US
dc.identifier.wosWOS:000239396500007
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofGynecological Endocrinology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectpolycystic ovary syndromeen_US
dc.subjectinsulin resistanceen_US
dc.subjectPro12Ala polymorphismen_US
dc.subjectperoxisome proliferator-activated receptor-gammaen_US
dc.subjectgeneen_US
dc.subjectandrogensen_US
dc.subjectobesityen_US
dc.titlePro12Ala polymorphism of the peroxisome proliferator-activated receptor-gamma gene in women with polycystic ovary syndromeen_US
dc.typeArticle

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