Effect of Iloprost® on endothelin-1-induced free radical activation in rabbit brain stem
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Tarih
2004
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info:eu-repo/semantics/closedAccess
Özet
Iloprost, a stable analogue of prostacyclin, was used to reverse the early period of vasoconstriction provoked by Endothelin-1 by administering into the rabbit basilar artery. We observed if this produced an effect on the central nervous system parenchyma mediated by free radical system. The red neurons were counted in brain stem sections stained with haematoxylin and eosin, while superoxide dismutase and malondialdehyde levels were measured in brain stem tissue samples as a marker of reactive oxygen metabolites; both 30 and 90min after administration of either Endothelin-1 (0.25ng) alone or Endothelin-1 followed by Iloprost (0.5?g/kg) into the basilar artery. Endothelin-1 significantly increased the number of red neurons, while Iloprost significantly reduced them after 30 and 90min. However, regarding the reactive oxygen metabolites; a similar reversing effect of Iloprost was not observed although superoxide dismutase levels were significantly decreased after Endothelin-1 infusion. © 2004 Elsevier Ltd. All rights reserved.
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Kaynak
Prostaglandins Leukotrienes and Essential Fatty Acids
WoS Q Değeri
Q3
Scopus Q Değeri
Q2
Cilt
71
Sayı
1
Künye
closedAccess
