Effect of Iloprost® on endothelin-1-induced free radical activation in rabbit brain stem

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dc.contributor.authorKeskil I.Semih
dc.contributor.authorBaykaner M. Kemali
dc.contributor.authorArıcıoğlu Aysel
dc.contributor.authorKaymaz Memduh
dc.contributor.authorUysal Selçuk
dc.contributor.authorAtaoğlu Ömür
dc.contributor.authorÇeviker Necdet
dc.date.accessioned2020-06-25T15:13:23Z
dc.date.available2020-06-25T15:13:23Z
dc.date.issued2004
dc.departmentKırıkkale Üniversitesi
dc.description.abstractIloprost, a stable analogue of prostacyclin, was used to reverse the early period of vasoconstriction provoked by Endothelin-1 by administering into the rabbit basilar artery. We observed if this produced an effect on the central nervous system parenchyma mediated by free radical system. The red neurons were counted in brain stem sections stained with haematoxylin and eosin, while superoxide dismutase and malondialdehyde levels were measured in brain stem tissue samples as a marker of reactive oxygen metabolites; both 30 and 90min after administration of either Endothelin-1 (0.25ng) alone or Endothelin-1 followed by Iloprost (0.5?g/kg) into the basilar artery. Endothelin-1 significantly increased the number of red neurons, while Iloprost significantly reduced them after 30 and 90min. However, regarding the reactive oxygen metabolites; a similar reversing effect of Iloprost was not observed although superoxide dismutase levels were significantly decreased after Endothelin-1 infusion. © 2004 Elsevier Ltd. All rights reserved.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1016/j.plefa.2003.11.011
dc.identifier.endpage11en_US
dc.identifier.issn09523278
dc.identifier.issue1en_US
dc.identifier.pmid15172678
dc.identifier.scopus2-s2.0-16544386667
dc.identifier.scopusqualityQ2
dc.identifier.startpage7en_US
dc.identifier.urihttps://doi.org/10.1016/j.plefa.2003.11.011
dc.identifier.urihttps://hdl.handle.net/20.500.12587/1764
dc.identifier.volume71en_US
dc.identifier.wosWOS:000222074600002
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.relation.ispartofProstaglandins Leukotrienes and Essential Fatty Acids
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.titleEffect of Iloprost® on endothelin-1-induced free radical activation in rabbit brain stemen_US
dc.typeArticle

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