Heterogeneity of damage between segments of rat liver after inflow-outflow obstruction

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dc.contributor.authorPolat, E.
dc.contributor.authorTopaloğlu, S.
dc.contributor.authorSökmensüer, C.
dc.contributor.authorTopaloğlu, E.
dc.contributor.authorAvşar, F. M.
dc.contributor.authorÖzel, H.
dc.contributor.authorHengirmen, S.
dc.date.accessioned2020-06-25T17:41:23Z
dc.date.available2020-06-25T17:41:23Z
dc.date.issued2006
dc.description.abstractBackground. Total vascular exclusion (TVE) causes warm liver ischernia. The complete explanation of the events during inflow and outflow obstruction of the liver during selective TVE has not yet been studied. The aim of this study was to investigate the liver injury caused by inflow-outflow obstruction in the rat liver. Materials and methods. Forty Wistar-Albino rats were divided into four groups. Liver inflow occlusion (groups A and C) or inflow-outflow occlusion (groups B and D) was applied for 30 minutes. Samples were collected at the end of the ischemia period. We examined oxidative injury in the liver tissue and liver histopathology. Results. Oxidative stress and histopathologic alterations were more prominent with TVE application. Significant alterations were shown in hepatic superoxide dismutase, glutathione, and glutathione S-transferase levels. Central segments of the rat liver were affected significantly from inflow occlusion, whereas dome segments were significantly damaged from inflow-outflow occlusion. Conclusions. Inflow-outflow occlusion of the liver caused more tissue damage compared with inflow occlusion. The pattern of distribution of the damage due to TVE seemed different from other well-known ischemia-reperfusion injuries.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1016/j.transproceed.2006.08.097
dc.identifier.endpage3081en_US
dc.identifier.issn0041-1345
dc.identifier.issn1873-2623
dc.identifier.issue9en_US
dc.identifier.pmid17112903
dc.identifier.scopus2-s2.0-33750959232
dc.identifier.scopusqualityQ3
dc.identifier.startpage3075en_US
dc.identifier.urihttps://doi.org10.1016/j.transproceed.2006.08.097
dc.identifier.urihttps://hdl.handle.net/20.500.12587/3699
dc.identifier.volume38en_US
dc.identifier.wosWOS:000242294500084
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier Science Incen_US
dc.relation.ispartofTransplantation Proceedings
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.titleHeterogeneity of damage between segments of rat liver after inflow-outflow obstructionen_US
dc.typeArticle

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