Potential Crown Discoloration Induced by the Combination of Various Intracanal Medicaments and Scaffolds Applied in Regenerative Endodontic Therapy

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dc.authoridTurkyilmaz, Ali/0000-0003-0641-0062
dc.contributor.authorAltun, N. B.
dc.contributor.authorTurkyilmaz, A.
dc.date.accessioned2025-01-21T16:43:32Z
dc.date.available2025-01-21T16:43:32Z
dc.date.issued2024
dc.departmentKırıkkale Üniversitesi
dc.description.abstractBackground:Regenerative endodontics involves the use of various root canal medicaments and scaffolds, which may cause crown discoloration. Aim:This study aimed to investigate the combined crown discoloration of scaffolds [platelet-rich fibrin (PRF) and blood clot] applied after administration of different medicaments [modified triple antibiotic paste including doxycycline (mTAPd), modified double antibiotic paste (mDAP), calcium hydroxide (CH), and propolis]. Methods:In total, 100 human mandibular premolar teeth were selected and prepared. The teeth were apically resected to simulate immature teeth. The positive and negative control groups (n = 10) consisted solely of blood-only and serum-only samples. The remaining 80 teeth were used for the experimental groups with four different medicaments. Three weeks later, either blood or PRF was applied as a scaffold after removing the medicaments (n = 10). Color changes were assessed before medication placement and at the end of the first, second, and third weeks, as well as on days 0, 1, 30, 60, and 90 after scaffold application. Analysis was carried out using repeated measures of variance, Friedman, one-way ANOVA, Kruskal-Wallis, the dependent paired t-test, and Wilcoxon test. Results:Statistical significance was determined at P = 0.05. All groups including blood and the group including propolis and PRF combination, resulted in a significant increase in discoloration (P < 0.05) and discoloration exceeding clinically acceptable thresholds. Conclusions:CH and the modified versions of TAP (mTAPd) and DAP (mDAP) demonstrated an acceptable level of discoloration when used with a combination of PRF at day 90.
dc.description.sponsorshipThis study is a part of thesis of Nihan Berkdemir Altun. The authors deny any conflict of interest related to this study. They have no financial or nonfinancial interests to disclose. The authors would like to thank Dr. Berat Serdar Akdeniz for his assistance with the use of digital camera set.
dc.identifier.doi10.4103/njcp.njcp_126_24
dc.identifier.endpage904
dc.identifier.issn1119-3077
dc.identifier.issn2229-7731
dc.identifier.issue7
dc.identifier.pmid39082917
dc.identifier.scopus2-s2.0-85200168095
dc.identifier.scopusqualityQ2
dc.identifier.startpage897
dc.identifier.urihttps://doi.org/10.4103/njcp.njcp_126_24
dc.identifier.urihttps://hdl.handle.net/20.500.12587/25289
dc.identifier.volume27
dc.identifier.wosWOS:001279176900013
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWolters Kluwer Medknow Publications
dc.relation.ispartofNigerian Journal of Clinical Practice
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241229
dc.subjectDouble antibiotic paste; platelet-rich fibrin; propolis; tooth discoloration; triple antibiotic paste
dc.titlePotential Crown Discoloration Induced by the Combination of Various Intracanal Medicaments and Scaffolds Applied in Regenerative Endodontic Therapy
dc.typeArticle

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