The association between total cholesterol and cognitive impairment in chronic obstructive pulmonary disease patients

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dc.authoridErdogan, Mehmet/0000-0002-2747-3823
dc.authoridOzturk, Hayriye Mihrimah/0000-0002-4857-931X
dc.contributor.authorOzturk, Hayriye Mihrimah
dc.contributor.authorOgan, Nalan
dc.contributor.authorErdogan, Mehmet
dc.contributor.authorAkpinar, Evrim Eylem
dc.contributor.authorIlgar, Ceren
dc.contributor.authorOzturk, Selcuk
dc.date.accessioned2025-01-21T16:44:53Z
dc.date.available2025-01-21T16:44:53Z
dc.date.issued2023
dc.departmentKırıkkale Üniversitesi
dc.description.abstractAim: Chronic obstructive pulmonary disease (COPD) is primarily a respiratory system disorder associated with extrapulmonary conditions. Cognitive impairment (CoI) is very common among COPD patients This study sought to investigate the association between CoI and clinical parameters, inflammatory markers and lipid profiles in a COPD patient population.Methods: The study population included 111 stable COPD patients. COPD was diagnosed according to Global Initiative for Chronic Obstructive Lung Disease guideline. Total complete blood count test and biochemical measurements including lipid profile were performed. Afterwards, all patients underwent neuropsychological assessment including Hospital Anxiety and Depression Scale (HADS), Pittsburgh Sleep Quality Index and Mon-treal Cognitive Assessment (MoCA) tests.Results: The patients were categorized into two groups according to their MoCA test score: MoCA score & LE; 21 (CoI) (n = 69) and MoCA score > 21 (normal cognition) (n = 42). Total cholesterol (TC) levels were significantly lower in patients with CoI compared to patients with normal cognition. Inflammation related parameters including C -reactive protein were similar among groups. Multivariate logistic regression analysis yielded education, HADS score and TC (OR:1.02, 95% CI:1.00-1.04, p = 0.025) as independent predictors of MoCA score.Conclusion: TC independently associates with CoI in COPD patients. There is comparable inflammatory status in COPD patients with CoI compared to COPD patients with normal cognition.
dc.identifier.doi10.1016/j.prostaglandins.2022.106697
dc.identifier.issn1098-8823
dc.identifier.issn2212-196X
dc.identifier.pmid36347442
dc.identifier.scopus2-s2.0-85141456886
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1016/j.prostaglandins.2022.106697
dc.identifier.urihttps://hdl.handle.net/20.500.12587/25543
dc.identifier.volume164
dc.identifier.wosWOS:001016514100001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier Science Inc
dc.relation.ispartofProstaglandins & Other Lipid Mediators
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241229
dc.subjectCholesterol; Chronic obstructive pulmonary disease; Cognitive impairment; Inflammation
dc.titleThe association between total cholesterol and cognitive impairment in chronic obstructive pulmonary disease patients
dc.typeArticle

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