A compilation answering 50 questions on Monkeypox virus and the current Monkeypox outbreak

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dc.authoridde las Vecillas Sanchez, Leticia/0000-0003-4969-5678
dc.authoridCastagnoli, Riccardo/0000-0003-0029-9383
dc.authoridAmbrozej, Dominika/0000-0003-3706-0210
dc.authoridFernandez-Santamaria, Ruben/0000-0002-0255-4280
dc.authoridMurdaca, Giuseppe/0000-0002-6403-6905
dc.authoridAkdis, Cezmi/0000-0001-8020-019X
dc.authoridGuemari, Amir/0000-0003-0343-9783
dc.contributor.authorCabanillas, Beatriz
dc.contributor.authorMurdaca, Giuseppe
dc.contributor.authorGuemari, Amir
dc.contributor.authorTorres, Maria Jose
dc.contributor.authorAzkur, Ahmet Kürşat
dc.contributor.authorAksoy, Emel
dc.contributor.authorVitte, Joana
dc.date.accessioned2025-01-21T16:34:56Z
dc.date.available2025-01-21T16:34:56Z
dc.date.issued2023
dc.departmentKırıkkale Üniversitesi
dc.description.abstractThe current monkeypox disease (MPX) outbreak constitutes a new threat and challenge for our society. With more than 55,000 confirmed cases in 103 countries, World Health Organization declared the ongoing MPX outbreak a Public Health Emergency of International Concern (PHEIC) on July 23, 2022. The current MPX outbreak is the largest, most widespread, and most serious since the diagnosis of the first case of MPX in 1970 in the Democratic Republic of the Congo (DRC), a country where MPX is an endemic disease. Throughout history, there have only been sporadic and self-limiting outbreaks of MPX outside Africa, with a total of 58 cases described from 2003 to 2021. This figure contrasts with the current outbreak of 2022, in which more than 55,000 cases have been confirmed in just 4 months. MPX is, in most cases, self-limiting; however, severe clinical manifestations and complications have been reported. Complications are usually related to the extent of virus exposure and patient health status, generally affecting children, pregnant women, and immunocompromised patients. The expansive nature of the current outbreak leaves many questions that the scientific community should investigate and answer in order to understand this phenomenon better and prevent new threats in the future. In this review, 50 questions regarding monkeypox virus (MPXV) and the current MPX outbreak were answered in order to provide the most updated scientific information and to explore the potential causes and consequences of this new health threat.
dc.description.sponsorshipTalento Investigador of the Community of Madrid (Regional Ministry of Science, Universities, and Innovation, Madrid, Spain [2019- T1/BIO-12690]; Instituto de Salud Carlos III (ISCIII) through the project [PI20/00351]; European Union; Spanish Ministry of Science and Innovation
dc.description.sponsorshipGrant from research program Talento Investigador of the Community of Madrid (Regional Ministry of Science, Universities, and Innovation, Madrid, Spain. Grant number: 2019- T1/BIO-12690). Grant from Instituto de Salud Carlos III (ISCIII) through the project PI20/00351 (Spanish Ministry of Science and Innovation) (Co-funded by the European Union).
dc.identifier.doi10.1111/all.15633
dc.identifier.endpage662
dc.identifier.issn0105-4538
dc.identifier.issn1398-9995
dc.identifier.issue3
dc.identifier.pmid36587287
dc.identifier.scopus2-s2.0-85146246822
dc.identifier.scopusqualityQ1
dc.identifier.startpage639
dc.identifier.urihttps://doi.org/10.1111/all.15633
dc.identifier.urihttps://hdl.handle.net/20.500.12587/24041
dc.identifier.volume78
dc.identifier.wosWOS:000913384300001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofAllergy
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241229
dc.subjectmonkeypox; orthopoxvirus; outbreak; viral infection; zoonosis
dc.titleA compilation answering 50 questions on Monkeypox virus and the current Monkeypox outbreak
dc.typeReview Article

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