The effect of different types of honey on healing infected wounds

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dc.contributor.authorEroglu, Oguz
dc.contributor.authorDeniz, Turgut
dc.contributor.authorKisa, Ucler
dc.contributor.authorComu, Faruk Metin
dc.contributor.authorKaygusuz, Sedat
dc.contributor.authorKocak, Orhan Murat
dc.date.accessioned2020-06-25T18:29:23Z
dc.date.available2020-06-25T18:29:23Z
dc.date.issued2018
dc.departmentKırıkkale Üniversitesi
dc.descriptionKISA, Ucler/0000-0002-8131-6810
dc.description.abstractObjective: To investigate the effects of treatments of 'mad honey', blossom honey and nitrofurazone on infected wound healing. Method: Male albino Wistar rats were randomly divided into four groups: 'mad honey' (MH), blossom honey (BH), nitrofurazone (N) and control (C). All rats were anaesthetised intraperitoneally. A circular skin incision was made to the back regions. Grafts containing slime-producing Staphylococcus epidermidis were placed on the incision area and then sutured to the skin. Infection in the wound area was confirmed after 48 hours. Wounds were dressed twice daily with the various treatment materials. Rats were randomly euthanised on days 7 or 14, and tissue samples taken. Tissue samples were assessed for hydroxyproline (HP), tensile strength (TS) and macroscopic measurement (area and intensity). Results: HP levels were higher in the treatment groups (MH, BH, N) at days 7 and 14 compared with the control group. 'Group x day' interaction was found in the HP levels (p=0.015). Increases in HP levels in the MH and N groups between days 7 and 14 were significantly higher than those in the other groups (p<0.05). Intensity was significantly lower in the control group and significantly higher in group MH compared with the other groups. Significant 'group x day' interaction was observed in intensity (p=0.006). TS was significantly lower on day 7 than on day 14 (p=0.022). No marked difference was observed between the groups, nor any 'group x day' interaction, in terms of TS. Conclusion: Honey administration successfully healed infected wounds. However, there was no significant difference between the effect of MH and that of N in terms of wound healing.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.12968/jowc.2018.27.Sup10.S18
dc.identifier.endpageS25en_US
dc.identifier.issn0969-0700
dc.identifier.issn2062-2916
dc.identifier.issue10en_US
dc.identifier.pmid30307813
dc.identifier.scopus2-s2.0-85054715642
dc.identifier.scopusqualityQ1
dc.identifier.startpageS18en_US
dc.identifier.urihttps://doi.org/10.12968/jowc.2018.27.Sup10.S18
dc.identifier.urihttps://hdl.handle.net/20.500.12587/7291
dc.identifier.volume27en_US
dc.identifier.wosWOS:000447063700004
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherMa Healthcare Ltden_US
dc.relation.ispartofJournal Of Wound Care
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjecthydroxyprolineen_US
dc.subjectinfected wounden_US
dc.subjectmad honeyen_US
dc.subjectnitrofurazoneen_US
dc.subjecttensile strengthen_US
dc.subjectwound healingen_US
dc.titleThe effect of different types of honey on healing infected woundsen_US
dc.typeArticle

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