What is the protective effect of krill oil on rat ovary against ischemia–reperfusion injury?

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dc.contributor.authorYeral I.
dc.contributor.authorSayan C.D.
dc.contributor.authorKaraca G.
dc.contributor.authorSimsek Y.
dc.contributor.authorSagsoz N.
dc.contributor.authorOzkan Z.S.
dc.contributor.authorAtasoy P.
dc.date.accessioned2021-01-14T18:16:13Z
dc.date.available2021-01-14T18:16:13Z
dc.date.issued2019
dc.departmentKKÜ
dc.description.abstractAim: In this study, we aimed to investigate the protective effect of krill oil (KO) against ischemia–reperfusion (I/R) injury on rat ovary. Methods: This study was conducted with 32 Wistar Albino rats. Rats were divided into four groups, with eight rats in each group-as follows: Sham group, I/R group, I/R + low dose KO group (50 mg) and I/R + high dose KO group (500 mg). The histopathological and follicle counts were performed on the right ovary. The total antioxidant status, total oxidant status and oxidative stress index were evaluated on the left ovary. And also serum N-thiol level, serum T-thiol level, serum disulfide (SDS) level, serum disulfide/N-thiol and serum disulfide/T-thiol ratios were evaluated too. Results: A statistically significant difference was determined between the I/R group and all the other groups for all parameters. There was significant difference between KO groups and the Sham group for the parameters of serum N-thiol, serum T-thiol, SDS, serum disulfide/N-thiol and serum disulfide/T-thiol. SDS, total oxidant status and oxidative stress index were determined to be the highest in the I/R group and the lowest in the low dose KO group. The total antioxidant status values were found to be the highest in the high dose KO group and the lowest in the I/R group. Follicle counts and histological injury scores showed no significant difference between Sham and KO groups. Conclusion: This study demonstrated that KO has beneficial effects on decreasing the injury after I/R on rat ovary. © 2018 Japan Society of Obstetrics and Gynecologyen_US
dc.description.sponsorship2018/003en_US
dc.description.sponsorshipThis research was funded by Kırıkkale University Scientific Research Commission (Project number: 2018/003). The authors are grateful to the staff members of Kırıkkale University for their valuable support.en_US
dc.identifier.citationBu makale açık erişimli değildir.en_US
dc.identifier.doi10.1111/jog.13876
dc.identifier.endpage599en_US
dc.identifier.issn1341-8076
dc.identifier.issue3en_US
dc.identifier.pmid30484932
dc.identifier.scopus2-s2.0-85057539439
dc.identifier.scopusqualityQ2
dc.identifier.startpage592en_US
dc.identifier.urihttps://doi.org/10.1111/jog.13876
dc.identifier.urihttps://hdl.handle.net/20.500.12587/13019
dc.identifier.volume45en_US
dc.identifier.wosWOS:000460180500012
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherBlackwell Publishingen_US
dc.relation.ispartofJournal of Obstetrics and Gynaecology Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectdynamic thiol-disulfide homeostasisen_US
dc.subjectfree oxygen radicalen_US
dc.subjectischemia–reperfusion injuryen_US
dc.subjectkrill oilen_US
dc.subjectraten_US
dc.titleWhat is the protective effect of krill oil on rat ovary against ischemia–reperfusion injury?en_US
dc.typeArticle

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