Evaluation of the combined effects of Turkish mad honey and 5-Fluorouracil in colon cancer model in rats

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dc.authoridGülendağ, Erman/0000-0002-3335-7247
dc.contributor.authorKurtdede, Efe
dc.contributor.authorAlcigir, Mehmet Eray
dc.contributor.authorAlperen, Ahmet Mahmut
dc.contributor.authorBaran, Berk
dc.contributor.authorKaraca, Oğuz Kaan
dc.contributor.authorGülendağ, Erman
dc.date.accessioned2025-01-21T16:33:58Z
dc.date.available2025-01-21T16:33:58Z
dc.date.issued2023
dc.departmentKırıkkale Üniversitesi
dc.description.abstractIt was aimed to evaluate the regressive effect of grayanotoxin-rich Turkish mad honey and 5-fluorouracil (5-FU), separately and together by using the Nmethyl-N-nitrosourea (MNU)-induced colon cancer modelling in rats. Study groups were designed as control group (CG), cancer control group (CCG), 5Flourouracil group (FUG), Turkish mad honey group (HG), Turkish mad honey and 5-FU combined group (FU-HG). White blood cell (WBC), lymphocyte, eosinophil, basophil, serum lactate dehydrogenase (LDH), total oxidant status (TOS), and total protein values of the rats in the CCG were significantly lower than the values of the rats in the CG, whereas serum Bcl-2 and survivin levels were significantly higher in the rates belonged to the CCG in comparison to those in the CG. The presence of anaplastic epithelial cells, vascularization, precancerous changes, and inflammatory infiltration detected in the colon and small intestine of the rats in FU-HG, FUG, HG were less intense (P<0.05) compared to the findings in the rats in CCG. In conclusion, mad honey and 5 FU reduced anaplastic cell growth and oxidative stress via suppressed antiapoptotic activity. Considering the histopathological findings in the liver and kidney, no toxicity occurred related to mad honey and 5-FU metabolization. Therefore, the combined use of these two substances may be an alternative method in the treatment of colon cancer.
dc.description.sponsorshipAnkara University Scientific Research Projects Coordinatorship [210239001]
dc.description.sponsorshipThis study was supported by Ankara University Scientific Research Projects Coordinatorship Grant No: 21OE0239001.
dc.identifier.doi10.33988/auvfd.1113279
dc.identifier.endpage435
dc.identifier.issn1300-0861
dc.identifier.issn1308-2817
dc.identifier.issue4
dc.identifier.scopus2-s2.0-85174043902
dc.identifier.scopusqualityQ3
dc.identifier.startpage427
dc.identifier.trdizinid1252149
dc.identifier.urihttps://doi.org/10.33988/auvfd.1113279
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay1252149
dc.identifier.urihttps://hdl.handle.net/20.500.12587/23889
dc.identifier.volume70
dc.identifier.wosWOS:001082844400009
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.publisherAnkara Univ
dc.relation.ispartofAnkara Universitesi Veteriner Fakultesi Dergisi
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241229
dc.subjectApoptosis; Colon cancer; Oxidative stress; Turkish mad honey
dc.titleEvaluation of the combined effects of Turkish mad honey and 5-Fluorouracil in colon cancer model in rats
dc.typeArticle

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