An Investigation of the Effects of Curcumin on the Changes in the Central Nervous System of Rats Exposed to Aroclor 1254 in the Prenatal Period

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dc.contributor.authorAlcigir, Mehmet Eray
dc.contributor.authorDogan, Halef Okan
dc.contributor.authorDikmen, Begum Yurdakok
dc.contributor.authorDogan, Kubra
dc.contributor.authorVural, Sevil Atalay
dc.contributor.authorYilmaz, Fatma Meric
dc.contributor.authorIsgoren, Atilla
dc.date.accessioned2020-06-25T18:30:02Z
dc.date.available2020-06-25T18:30:02Z
dc.date.issued2018
dc.departmentKırıkkale Üniversitesi
dc.descriptionYurdakok-Dikmen, Begum/0000-0002-0385-3602
dc.description.abstractBackground & Objective: Aroclor 1254 is a widespread toxic compound of Polychlorinated Biphenyls (PCBs), which can create significant nervous problems. No remedies have been found to date. The aim of this study was to reveal the damage that occurs in the central nervous system of rat pups exposed to Aroclor 1254 in the prenatal period and to show the inhibiting effect of curcumin, which is a strong anti-oxidant and neuroprotective substance. Method: The study established 3 groups of adult female and male Wistar albino rats. The rats were mated within these groups and the offspring rats were evaluated within the group given Aroclor 1254 only (n=10) and the group was given both Aroclor 1254 and curcumin (n=10) and the control group (n=10). The groups were compared in respect of pathomorphological damage. The immunohistochemical evaluation was made of 8-hydroxdeoxyguanosine (8-OHdG), 4-hydroxynoneal (4HNE), myelin basic protein (MBP) expressions and TUNEL reaction. The biochemical evaluation was made of the changes in the TAS-TOS and Neuron Specific Enolase (NSE) levels. Damage was seen to have been reduced with curcumin in the 8OHdG and TUNEL reactions, especially in the forebrain and the midbrain, although the dosage applied did not significantly change TAS and TOS levels. Consequently, it was understood that Aroclor 1254 caused damage in the central nervous system of the pup in the prenatal period, and curcumin reduced these negative effects, particularly in the forebrain and the midbrain. Conclusion: It was concluded that curcumin could be a potential neuroprotective agent and would be more effective at higher doses.en_US
dc.description.sponsorshipScientific and Technological Research Projects Funding Program (TUBITAK) [214O124]en_US
dc.description.sponsorshipThis study was supported by funding received from the Scientific and Technological Research Projects Funding Program (TUBITAK) under project number 214O124.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.2174/1871527317666180315170146
dc.identifier.endpage143en_US
dc.identifier.issn1871-5273
dc.identifier.issn1996-3181
dc.identifier.issue2en_US
dc.identifier.pmid29546838
dc.identifier.scopus2-s2.0-85049083039
dc.identifier.scopusqualityQ2
dc.identifier.startpage132en_US
dc.identifier.urihttps://doi.org/10.2174/1871527317666180315170146
dc.identifier.urihttps://hdl.handle.net/20.500.12587/7539
dc.identifier.volume17en_US
dc.identifier.wosWOS:000435906600008
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherBentham Science Publen_US
dc.relation.ispartofCns & Neurological Disorders-Drug Targets
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAroclor 1254en_US
dc.subjectbiochemistryen_US
dc.subjectcurcuminen_US
dc.subjectimmunohistochemistryen_US
dc.subjectpathomorphologyen_US
dc.subjectrat pupsen_US
dc.titleAn Investigation of the Effects of Curcumin on the Changes in the Central Nervous System of Rats Exposed to Aroclor 1254 in the Prenatal Perioden_US
dc.typeArticle

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