In vivo performance of antibiotic embedded electrospun PCL membranes for prevention of abdominal adhesions

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dc.contributor.authorBölgen, N.
dc.contributor.authorVargel, İ.
dc.contributor.authorKorkusuz, P.
dc.contributor.authorMenceloglu, Y. Z.
dc.contributor.authorPişkin, E.
dc.date.accessioned2020-06-25T17:43:49Z
dc.date.available2020-06-25T17:43:49Z
dc.date.issued2007
dc.descriptionBolgen, Nimet/0000-0003-3162-0803; Bolgen, Nimet/0000-0003-3162-0803; Menceloglu, Yusuf/0000-0003-0296-827X; KORKUSUZ, PETEK/0000-0002-7553-3915
dc.description.abstractThe aim of this study was to prepare nonwoven materials from poly(epsilon-caprolactone) (PCL) and their antibiotic containing forms by electrospinning, so as to prevent postsurgery induced abdominal adhesions in rats. epsilon-Caprolactone was first polymerized by ring-opening polymerization, and then it was processed into matrices composed of nanofibers by electrospinning. A model antibiotic (Biteral(R)) was embedded within a group of PCL membranes. In the rat model, defects on the abdominal walls in the peritoneum were made to induce adhesion. The plain or antibiotic embedded PCL membranes were implanted on the right side of the abdominal wall. No membrane implantation was made on the left side of the abdominal wall that served as control. Macroscopical and histological evaluations showed that using these barriers reduces the extent, type, and tenacity of adhesion. The antibiotic embedded membranes significantly eliminated postsurgery abdominal adhesions, and also improved healing. (C) 2006 Wiley Periodicals, Inc.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1002/jbm.b.30694
dc.identifier.endpage543en_US
dc.identifier.issn1552-4973
dc.identifier.issn1552-4981
dc.identifier.issue2en_US
dc.identifier.pmid17041925
dc.identifier.scopus2-s2.0-34247567790
dc.identifier.scopusqualityQ1
dc.identifier.startpage530en_US
dc.identifier.urihttps://doi.org10.1002/jbm.b.30694
dc.identifier.urihttps://hdl.handle.net/20.500.12587/3911
dc.identifier.volume81Ben_US
dc.identifier.wosWOS:000246004400031
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWileyen_US
dc.relation.ispartofJournal Of Biomedical Materials Research Part B-Applied Biomaterials
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectabdominal adhesionen_US
dc.subjectanimal modelen_US
dc.subjectelectrospinningen_US
dc.subjectnonwoven membranesen_US
dc.subjectbiodegradable nanofibersen_US
dc.subjectpoly (epsilon-caprolactone)en_US
dc.titleIn vivo performance of antibiotic embedded electrospun PCL membranes for prevention of abdominal adhesionsen_US
dc.typeArticle

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