Antimicrobial activity of cefazolin-impregnated mesh grafts

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dc.contributor.authorKılıç, Dilek
dc.contributor.authorAgalar, Canan
dc.contributor.authorÖztürk, Eylem
dc.contributor.authorDenkbaş, Emir B.
dc.contributor.authorCime, Abdullah
dc.contributor.authorAgalar, Fatih
dc.date.accessioned2020-06-25T17:43:51Z
dc.date.available2020-06-25T17:43:51Z
dc.date.issued2007
dc.descriptionGUVEN, EYLEM/0000-0001-9039-1698
dc.description.abstractBackground: The aim of this study is the preparation and characterization of cefazolin-impregnated meshes (Surgipro; Tyco Healthcare USSC, Norwalk, CT, USA) to be used as antimicrobial devices. Method: During the impregnation, poly(DL-lactide-co-glycolide) solution with cephazolin in dichloromethane was used as coating material. In vitro release experiment was carried out first; later cefazolin-impregnated meshes were evaluated for the characteristics of antimicrobial efficacy and in the last part of the study native and cefazolin-impregnated meshes were implanted in the rats. Cefazolin content was proposed as the effective parameter to control the cefazolin release rate and it was concluded that the higher amounts of initial cefazolin content caused higher release rates. In all cases (or with different cefazolin content for each mesh), the release rates were very rapid in the first 24 h and in the following periods rather slow release rates were obtained. Results: Antimicrobial activity was increased in the case of cefazolin-impregnated form and this efficiency was also increased by the higher amount of cefazolin in certain mesh pieces. Similar antimicrobial activities were observed in the in vitro studies. Conclusion: In this study, almost all of the cefazolin-impregnated mesh grafts showed very high antimicrobial activity compared with the bare mesh (or mesh without cefazolin).en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1111/j.1445-2197.2007.04029.x
dc.identifier.endpage260en_US
dc.identifier.issn1445-1433
dc.identifier.issue4en_US
dc.identifier.pmid17388831
dc.identifier.scopus2-s2.0-33947136885
dc.identifier.scopusqualityQ2
dc.identifier.startpage256en_US
dc.identifier.urihttps://doi.org10.1111/j.1445-2197.2007.04029.x
dc.identifier.urihttps://hdl.handle.net/20.500.12587/3924
dc.identifier.volume77en_US
dc.identifier.wosWOS:000244793700012
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherBlackwell Publishingen_US
dc.relation.ispartofAnz Journal Of Surgery
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectantimicrobial activityen_US
dc.subjectcefazolin impregnationen_US
dc.subjectcefazolin releaseen_US
dc.subjectmesh graften_US
dc.titleAntimicrobial activity of cefazolin-impregnated mesh graftsen_US
dc.typeArticle

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