Tumour Budding Is a Useful Predictor to Identify High-Risk Stage II Colon Cancer Patients After Curative Surgery

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dc.contributor.authorZengin, Mehmet
dc.contributor.authorIsikci, Ozlem Tanas
dc.date.accessioned2025-01-21T16:55:43Z
dc.date.available2025-01-21T16:55:43Z
dc.date.issued2024
dc.departmentKırıkkale Üniversitesi
dc.description.abstractAim. Although it is now accepted in the literature that tumour budding (TB) is a useful survival indicator in colon cancer (CC), there are still uncertainties about daily use. Here we methodologically examined the role of TB on survival in CC. Methods. In our study, we examined colon cancer patients who had surgery up to 15 years before presentation. TB was calculated separately using different comprehensive methodological methods. Results. We first investigated an optimal evaluation method. Relationship with prognostic factors was better (Venous invasion [p = .001], advanced pT [p = .003], perineural invasion [p = .040], MSS [p = .016], advanced size [p = .001], tumour obstruction [p = .005], margin involvement [p = .043], and nodal involvement [p = .028]) in Method-1. Similarly, with the same method, the success of the cut-off value, the correlation of TB data (r = .724), and the repeatability of the method (Kappa appa = .53-.75) were quite good (ROC = .816 [.707-.925]). Then, survival analysis was performed using the best three methods, including this method. In univariate analysis using Method-1, survival analyses were worse in high TB patients (RFS: 81%, p < .001; OS: 84%, p < .001). Multivariate analyses using the same method confirmed that high TB for RFS and OS was an independent poor prognostic parameter for survival (p = .002, Hazard ratio [HR]: 1.42 [1.13-1.80]) and OS (p = .014, HR: 1.38 [1.07-1.79]). Conclusions. With our study, we showed that tumour budding calculated by the standard method is a very valuable prognostic parameter in stage II CC and can contribute to the detection of patients with poor prognosis in stage II CC.
dc.description.sponsorshipWe would like to thank the staff of the Department of Pathology for their support at all stages of our study.
dc.identifier.doi10.1177/10668969241265017
dc.identifier.issn1066-8969
dc.identifier.issn1940-2465
dc.identifier.pmid39094576
dc.identifier.scopus2-s2.0-85200109387
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1177/10668969241265017
dc.identifier.urihttps://hdl.handle.net/20.500.12587/25815
dc.identifier.wosWOS:001283455100001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSage Publications Inc
dc.relation.ispartofInternational Journal of Surgical Pathology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241229
dc.subjectcolon cancer; tumour budding; prognostic markers; stage II
dc.titleTumour Budding Is a Useful Predictor to Identify High-Risk Stage II Colon Cancer Patients After Curative Surgery
dc.typeArticle

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