Bioengineering functional copolymers. XIV. Synthesis and interaction of poly(N-isopropylacrylamide-co-3,4-dihydro-2H-pyran-alt-maleic anhydride)s with SCLC cancer cells

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dc.contributor.authorTürk, Mustafa
dc.contributor.authorRzayev, Zakir M. O.
dc.contributor.authorKhalilova, Sevda A.
dc.date.accessioned2020-06-25T17:49:06Z
dc.date.available2020-06-25T17:49:06Z
dc.date.issued2010
dc.departmentKırıkkale Üniversitesi
dc.description.abstractNovel antitumor active functional polymers with supramacromolecular structures were synthesized by a complex-radical terpolymerization of N-isopropylacrylamide (NIPAm), 3,4-dihydro-2H-pyran (DHP), and maleic anhydride (MA) with 2,2'-azoisobisbutyronitrile as a radical initiator in 1,4-dioxane at 65 degrees C under nitrogen atmosphere. The structure and composition of terpolymers were investigated by H-1 (C-13) NMR spectroscopy. Interaction of terpolymers with human lung small cell carcinoma (SCLC) were investigated by using different methods such as cytotoxicity, statistical, apoptotic and necrotic cell indexes, double staining and caspase-3 immunostaining, light and fluorescence inverted microscopy analyses. Investigations into structure, composition, and antitumor activity relationships revealed that terpolymers containing a combination of ionisable amide-pyran linkages and H-bonded carboxylic groups exhibited higher cytotoxicity. It was observed that terpolymer with nearly alternating structure provides a maximum concentration of ionisable and H-bonded antitumor sites, and therefore, exhibits higher in vitro cytotoxicity, apoptotic and necrotic effects towards SCLC cancer cells. (C) 2010 Elsevier Ltd. All rights reserved.en_US
dc.description.sponsorshipHU Scientific Research FoundationHacettepe University [HU-BAB-0201602006]; TUBITAK (Turkish National Scientific and Technology Research Council)Turkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [TBAG-2386]en_US
dc.description.sponsorshipThis work was carried out in according to the Polymer Science and Engineering of the Chemical Engineering Department, Hacettepe University (HU) relating to the series 'Bioengineering Functional Copolymers'. The supports of the HU Scientific Research Foundation through the HU-BAB-0201602006 project and the TUBITAK (Turkish National Scientific and Technology Research Council) via TBAG-2386 project are gratefully acknowledged.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1016/j.bmc.2010.09.031
dc.identifier.endpage7984en_US
dc.identifier.issn0968-0896
dc.identifier.issn1464-3391
dc.identifier.issue22en_US
dc.identifier.pmid20943403
dc.identifier.scopus2-s2.0-78449232651
dc.identifier.scopusqualityQ1
dc.identifier.startpage7975en_US
dc.identifier.urihttps://doi.org/10.1016/j.bmc.2010.09.031
dc.identifier.urihttps://hdl.handle.net/20.500.12587/4636
dc.identifier.volume18en_US
dc.identifier.wosWOS:000283649900033
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherPergamon-Elsevier Science Ltden_US
dc.relation.ispartofBioorganic & Medicinal Chemistry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectSynthesisen_US
dc.subjectFunctional copolymersen_US
dc.subjectSCLC cancer cellsen_US
dc.subjectStructure-antitumor activity relationsen_US
dc.subjectCytotoxicityen_US
dc.subjectApoptotic and necrotic effectsen_US
dc.titleBioengineering functional copolymers. XIV. Synthesis and interaction of poly(N-isopropylacrylamide-co-3,4-dihydro-2H-pyran-alt-maleic anhydride)s with SCLC cancer cellsen_US
dc.typeArticle

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