DNA damage and its relationship with other oxidative stress parameters in Behcet's disease

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dc.contributor.authorSezer, E. D.
dc.contributor.authorAksu, K.
dc.contributor.authorCaglayan, O.
dc.contributor.authorKeser, G.
dc.contributor.authorKarabulut, G.
dc.contributor.authorErcan, G.
dc.date.accessioned2020-06-25T18:06:52Z
dc.date.available2020-06-25T18:06:52Z
dc.date.issued2012
dc.departmentKırıkkale Üniversitesi
dc.descriptionaksu, kenan/0000-0001-8889-2688
dc.description.abstractBeh double dagger et's disease (BD) is a multisystemic, chronic inflammatory, relapsing disorder that is characterized by oral/genital ulcerations, ocular, arthritic, vascular, and neurologic involvements. Recent findings suggest the role of increased oxidative stress and insufficient antioxidant defence system in BD pathogenesis. It has been proposed that the increase in phagocytic cell activity by triggering oxidative reactions in various targets such as lipids, proteins, and DNA leads to severe inflammatory and degenerative pathologies seen in BD In this study, oxidant/antioxidant status of patients with BD was evaluated in comparison with controls and in respect to disease activity by measuring serum nitrite/nitrate, vitamin A, malondialdehyde (MDA), 8-hydroxy deoxyguanosine (8-OHdG), and total sulfhydryl levels (T-SH). The increase in serum MDA and 8-OHdG levels (respectively 30.04 vs. 17.93 nmol/ml, P = 0.0004 and 1.60 vs. 1.03 ng/ml, P = 0.0019) and the decrease in T-SH levels of patients with BD in comparison with controls (0.69 vs. 0.76 mmol/l, P = 0.0085) all indicate the impaired oxidant/antioxidant status in BD. The positive correlation found between MDA/8-OHdG levels (P = 0.02), and the negative correlations both between T-SH/8-OHdG levels (P = 0.031) and T-SH/MDA levels (P = 0.009) show the concordance between the parameters evaluating oxidant-antioxidant status. Among the parameters used for evaluating oxidant/antioxidant status, serum 8-OHdG was the only one showing significantly higher levels in patients with clinically active disease in comparison (P = 0.004) to patients in inactive period. Therefore, 8-OHdG that is assessed for the fist time in BD with this study can be proposed as a more reliable indicator of oxidant stress in evaluating disease activity.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1007/s00296-010-1605-0
dc.identifier.endpage222en_US
dc.identifier.issn0172-8172
dc.identifier.issue1en_US
dc.identifier.pmid20838796
dc.identifier.scopus2-s2.0-84857121046
dc.identifier.scopusqualityQ1
dc.identifier.startpage217en_US
dc.identifier.urihttps://doi.org/10.1007/s00296-010-1605-0
dc.identifier.urihttps://hdl.handle.net/20.500.12587/5390
dc.identifier.volume32en_US
dc.identifier.wosWOS:000299007300034
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringer Heidelbergen_US
dc.relation.ispartofRheumatology International
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBehcet's diseaseen_US
dc.subjectOxidative stressen_US
dc.subjectDNA damageen_US
dc.subject8-Hydroxy deoxyguanosineen_US
dc.subjectMalondialdehydeen_US
dc.subjectTotal sulfhydrylen_US
dc.subjectNitrite/nitrateen_US
dc.subjectVitamin Aen_US
dc.titleDNA damage and its relationship with other oxidative stress parameters in Behcet's diseaseen_US
dc.typeArticle

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