Biological activity and molecular docking studies of some new quinolines as potent anticancer agents

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dc.authoridÖkten, Salih/0000-0001-9656-1803
dc.authoridKul Köprülü, Tuğba/0000-0001-9451-5715
dc.contributor.authorKöprülü, Tuğba Kul
dc.contributor.authorÖkten, Salih
dc.contributor.authorAtalay, Vildan Enisoglu
dc.contributor.authorTekin, Şaban
dc.contributor.authorÇakmak, Osman
dc.date.accessioned2025-01-21T16:36:11Z
dc.date.available2025-01-21T16:36:11Z
dc.date.issued2021
dc.departmentKırıkkale Üniversitesi
dc.description.abstractThe objective of this study is to investigate the antiproliferative and cytotoxic properties and the action mechanism of substituted quinoline and tetrahydroquinolines 3, 4, 5, 7, and 8 against rat glioblastoma (C6), human cervical cancer (HeLa), human adenocarcinoma (HT29) cancer cell lines by BrdU Cell Proliferation ELISA, Lactate Dehydrogenase, DNA laddering and Topoisomerase I assays. The results of the study showed that 6,8-dibromotetrahydroquinoline 3 possess in vitro antiproliferative activity against C6, HeLa, and HT29 cell lines while morpholine/piperazine substituted quinoline 7 and 8 showed selective antiproliferative activity on C6 cell line with IC50 values 47.5 and 46.3 mu g/mL, respectively. Moreover, 6,8-dibromoTHQ 3 caused DNA fragmentation while it did not inhibit the Topoisomerase I (Topo I) enzyme. On the other hand, compound 8 did not cause DNA laddering while 8 inhibited the Topo I enzyme. According to these results, 6,8-dibromoTHQ 3 stimulates apoptosis on the C6 cell line while 6,8-dibromo-3-morhonilylquinoline (8) inhibits the Topo I enzyme to cause antiproliferative activity. Graphic abstract
dc.description.sponsorshipScientific and Technological Research Council of Turkey (TUBITAK) [112T394]
dc.description.sponsorshipThis study was supported financially by the Scientific and Technological Research Council of Turkey (TUBITAK; 112T394).
dc.identifier.doi10.1007/s12032-021-01530-w
dc.identifier.issn1357-0560
dc.identifier.issn1559-131X
dc.identifier.issue7
dc.identifier.pmid34146171
dc.identifier.scopus2-s2.0-85108141315
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1007/s12032-021-01530-w
dc.identifier.urihttps://hdl.handle.net/20.500.12587/24274
dc.identifier.volume38
dc.identifier.wosWOS:000691898600001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherHumana Press Inc
dc.relation.ispartofMedical Oncology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241229
dc.subjectQuinoline; Tetrahydroquinoline; Anticancer activity; Cytotoxicity; Molecular docking
dc.titleBiological activity and molecular docking studies of some new quinolines as potent anticancer agents
dc.typeArticle

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