Evaluation of thiol-disulphide homeostasis in radiation workers

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dc.contributor.authorKoc, Ural
dc.contributor.authorTan, Sinan
dc.contributor.authorErtem, Ahmet Goktug
dc.contributor.authorGumus, Mehmet
dc.contributor.authorOzbek, Betul
dc.contributor.authorErel, Ozcan
dc.date.accessioned2020-06-25T18:23:36Z
dc.date.available2020-06-25T18:23:36Z
dc.date.issued2017
dc.departmentKırıkkale Üniversitesi
dc.descriptionEREL, Ozcan/0000-0002-2996-3236
dc.description.abstractPurpose: To evaluate thiol-disulphide homeostasis - a novel, easily calculated, readily available, and relatively cheap oxidative stress marker - in radiation workers and compare the results with healthy controls.Materials and methods: A total of 108 participants were enrolled in the study including 63 hospital workers occupationally exposed to ionizing radiation in the units of interventional radiology, interventional cardiology and nuclear medicine. A control group consisted of 45 individuals staff in the same hospital. Serum thiol-disulphide homeostasis measurement was investigated via the spectrophotometric method newly described by Erel and Neeliolu.Results: The mean serum native thiol levels of radiation workers (528.9686.42mol/l) was significantly lower than control subjects (561.05 +/- 104.83mol/l) (p=.045). The mean serum total thiol levels of radiation workers (547.70 +/- 91.50mol/l) was lower than control subjects (580.36 +/- 112.24mol/l). Nevertheless, there was no significant difference between total thiol of exposed workers and controls.Conclusions: The results show that long-term low dose ionizing radiation may lead to oxidative stress and have side-effects in antioxidant thiol groups. We may suggest supporting radiation workers by safe antioxidant nutritional formulations and following up via both physical dosimetry and biodosimetric methods.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1080/09553002.2017.1304668
dc.identifier.endpage710en_US
dc.identifier.issn0955-3002
dc.identifier.issn1362-3095
dc.identifier.issue7en_US
dc.identifier.pmid28281400
dc.identifier.scopus2-s2.0-85016939862
dc.identifier.scopusqualityQ2
dc.identifier.startpage705en_US
dc.identifier.urihttps://doi.org/10.1080/09553002.2017.1304668
dc.identifier.urihttps://hdl.handle.net/20.500.12587/7143
dc.identifier.volume93en_US
dc.identifier.wosWOS:000404729600007
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofInternational Journal Of Radiation Biology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectThiolen_US
dc.subjectdisulphideen_US
dc.subjectradiation workersen_US
dc.titleEvaluation of thiol-disulphide homeostasis in radiation workersen_US
dc.typeArticle

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