Contribution of amniotic membrane to the healing of iatrogenic vas deferens injury

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dc.authoridDemir, Sabri/0000-0003-4720-912X
dc.authoridErtürk, Ahmet/0000-0003-0286-362X
dc.authoridYildiz, Dinçer/0000-0002-3429-7223
dc.authoridKarahan, Siyami/0000-0002-2744-1717
dc.contributor.authorDemir, Sabri
dc.contributor.authorErtürk, Ahmet
dc.contributor.authorZengin, Mehmet
dc.contributor.authorYıldız, Dinçer
dc.contributor.authorKarahan, Siyami
dc.contributor.authorSenel, Emrah
dc.date.accessioned2025-01-21T16:34:28Z
dc.date.available2025-01-21T16:34:28Z
dc.date.issued2021
dc.departmentKırıkkale Üniversitesi
dc.description.abstractBackground/aim: Iatrogenic vas deferens injury is one of the most serious complications of operations in the inguinal region. Vasovasostomy is performed as treatment. However, stenosis is common after vasovasostomy. Oligospermia or azoospermia may develop and result in infertility. This study aimed to investigate the effect of amniotic membrane on healing in vas deferens injuries. Materials and methods: Four groups consisting of 10 rats each were formed. No procedure was performed in Group-I. In Group -II, the left vas deferens was transected and left to spontaneous healing. In Group-III, the left vas deferens was transected, and end -to-end anastomosis was performed. In Group-IV, the left vas deferens was transected, end-to-end anastomosis was performed, and it was closed with a wrapping of amniotic membrane on the anastomosis line. Rats were sacrificed after 60 days, and each left vas deferens was evaluated. Lumen patency was checked by passing methylene blue through the vas deferens. Subsequently, the vas deferens was evaluated both macroscopically and histopathologically. Data were evaluated using SPSS version 21.0. p < 0.05 was considered statistically significant for all variables. Results: The anastomosis lines in Group-IV healed better than those in Group-III, and less stenosis was observed. There were differences between the groups in terms of luminal patency (p = 0.009), adhesions to surrounding tissues (p = 0.02) and separation of the ends of the vas deferens (p = 0.03). Conclusion: We observed improvement on luminal patency and histology of rat vas deferens injury after surrounding human amniotic membrane on the transected and repaired surface. Further studies are needed to apply this promising result on human beings.
dc.description.sponsorshipScientific Research Projects Coordination Unit of Kirikkale University (KU-BAP) [2017-074]
dc.description.sponsorshipThis study was supported by a grant (No: 2017-074) of the Scientific Research Projects Coordination Unit of Kirikkale University (KU-BAP).
dc.identifier.doi10.3906/sag-2012-287
dc.identifier.endpage1571
dc.identifier.issn1300-0144
dc.identifier.issn1303-6165
dc.identifier.issue3
dc.identifier.pmid33726480
dc.identifier.scopus2-s2.0-85110051430
dc.identifier.scopusqualityQ1
dc.identifier.startpage1564
dc.identifier.trdizinid483343
dc.identifier.urihttps://doi.org/10.3906/sag-2012-287
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay483343
dc.identifier.urihttps://hdl.handle.net/20.500.12587/23971
dc.identifier.volume51
dc.identifier.wosWOS:000668257500018
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTubitak Scientific & Technological Research Council Turkey
dc.relation.ispartofTurkish Journal of Medical Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241229
dc.subjectAmniotic membrane; anastomosis; inguinal hernia; vas deferens; vasovasostomy
dc.titleContribution of amniotic membrane to the healing of iatrogenic vas deferens injury
dc.typeArticle

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