Effect of chronic and short-term erythropoietin treatment on random flap survival in rats: An experimental study

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dc.contributor.authorSaray, A
dc.contributor.authorOzakpinar, R
dc.contributor.authorKoc, C
dc.contributor.authorSerel, S
dc.contributor.authorSen, Z
dc.contributor.authorCan, Z
dc.date.accessioned2020-06-25T17:35:41Z
dc.date.available2020-06-25T17:35:41Z
dc.date.issued2003
dc.departmentKırıkkale Üniversitesi
dc.descriptionCan, Zeki/0000-0002-3484-7686
dc.description.abstractObjective: The use of perioperative erythropoietin (EPO) therapy is gaining popularity to avoid blood transfusion and correct anemia in head and neck cancer surgery. The purpose of the study was to determine the effect of various doses and durations of EPO treatment on random flap survival. Study Design: A McFarlane type random and musculocutaneous (3 X 10 cm) flap were elevated on the dorsum of each rat. Methods. Eighty-four male Albino rats were randomly assigned into seven groups (2 animals in each group): group 1, control animals receiving placebo; group 11, chronic EPO injections (50 U/kg); group 111, chronic EPO injections (100 mg/kg); group IV, chronic EPO injections (150 mg/kg); group V, short-term EPO injections (50 mg/kg); group VI, short-term EPO injections (100 mg/kg); and group VII, short-term EPO injections (150 mg/kg). Rats in groups 11 to IV began to receive EPO 3 weeks (thrice weekly) before the construction of flaps, and rats in groups V to VII received EPO after flap elevation for 1 week (thrice) subcutaneously. Following 7 days of recovery, the area of flap survival was measured. Hematocrit and systolic blood pressure were followed weekly in all groups. Results. Erythropoietin increased the hematocrit levels and systolic blood pressure in all groups, but significant increases were noted only in the long-term treatment groups. There was a significant increase in distal necrosis of random skin flaps after long-term EPO treatment (P <.05). However, short-term low and therapeutic doses of EPO improved flap survival significantly (P <.05). Conclusions. Long-term EPO treatment might have impaired flap survival because of direct or prostaglandin-mediated vasoconstriction, endothelin-induced hypertension, increased peripheral vascular resistance, hyperviscosity, and increased thrombosis. However, EPO might have enhanced flap survival because of its antioxidant effect and modulation of nitric oxide levels. Effects of EPO are controversial, and further research is necessary to delineate the dose and duration relationship and the exact mechanism of action on flap viability.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1097/00005537-200301000-00016
dc.identifier.endpage89en_US
dc.identifier.issn0023-852X
dc.identifier.issue1en_US
dc.identifier.pmid12514388
dc.identifier.scopus2-s2.0-0037221087
dc.identifier.scopusqualityQ1
dc.identifier.startpage85en_US
dc.identifier.urihttps://doi.org/10.1097/00005537-200301000-00016
dc.identifier.urihttps://hdl.handle.net/20.500.12587/3183
dc.identifier.volume113en_US
dc.identifier.wosWOS:000180499500016
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.ispartofLaryngoscope
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjecterythropoietinen_US
dc.subjectrandom skin flapen_US
dc.subjectsurvivalen_US
dc.titleEffect of chronic and short-term erythropoietin treatment on random flap survival in rats: An experimental studyen_US
dc.typeArticle

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