Autocrine motility factor receptor expression implies an unfavourable prognosis in resected stage I pulmonary adenocarcinomas

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dc.contributor.authorKaynak, Kübra
dc.contributor.authorKara, Meriem
dc.contributor.authorÖz, Büge
dc.contributor.authorAkgöz, Bekir
dc.contributor.authorSar, Mehmet
dc.contributor.authorRaz, Avraham
dc.date.accessioned2020-06-25T17:40:28Z
dc.date.available2020-06-25T17:40:28Z
dc.date.issued2005
dc.departmentKırıkkale Üniversitesi
dc.description18th Annual Meeting of the European-Association-for-Cardiothoracic-Surgery/12th Annual Meeting of the European-Society-of-Thoracic-Surgeons -- SEP 12-15, 2004 -- Leipzig, GERMANY
dc.description.abstractBackground : Pulmonary adenocarcinomas constitute a different histological subtype among the histological subtypes of non small cell lung carcinomas by showing comparably unfavourable rates of prognosis and different immunobiological features. Autonomous motility of tumour cells plays an important role in the regulation of local invasion and distant metastasis of tumour lesions which have great impact on overall survival. AMF (Autocrine motility factor) is a tumour secreted cytokine that stimulates motility during invasion and metastasis via its receptor, AMFR. We conducted an immunohistochemical study to investigate AMFR expression in pulmonary adenocarcinomas and its effect on survival. Material and methods: We assessed AMFR expression using a monoclonal antibody (3F3A) in a total of 32 surgical specimens with stage I pulmonary adenocarcinomas that underwent curative resection. We analyzed AMFR expression as a possible prognostic factor on survival and its correlations with clinicopathological features. Results: A total of 19 (59.3%) specimens showed AMFR expression. The 3-year survival rates of AMFR positive and AMFR negative patients were 47.3% and 84.6%, respectively, which was a significant difference (P = 0.0197). The univariate predictors of surgical outcome were AMFR expression (P = 0.032) and perineural invasion (P = 0.038). However, multivariate analysis revealed AMFR expression (P = 0.045) as the only independent prognostic factor. Conclusions : AMFR expression predicts an unfavourable surgical outcome in patients with stage I pulmonary adenocarcinomas.en_US
dc.description.sponsorshipEuropean Assoc Cardiothorac Surg, European Soc Thorac Surgen_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1080/00015458.2005.11679740
dc.identifier.endpage382en_US
dc.identifier.issn0001-5458
dc.identifier.issue4en_US
dc.identifier.pmid16184720
dc.identifier.scopus2-s2.0-24644448848
dc.identifier.scopusqualityQ3
dc.identifier.startpage378en_US
dc.identifier.urihttps://doi.org/10.1080/00015458.2005.11679740
dc.identifier.urihttps://hdl.handle.net/20.500.12587/3448
dc.identifier.volume105en_US
dc.identifier.wosWOS:000231906000010
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofActa Chirurgica Belgica
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectautocrine motility factor receptoren_US
dc.subjectlung canceren_US
dc.subjectadenocarcinomaen_US
dc.titleAutocrine motility factor receptor expression implies an unfavourable prognosis in resected stage I pulmonary adenocarcinomasen_US
dc.typeArticle

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