Expression of laminin-1 and matrix metalloproteinase-9 in benign and malignant endometrium

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dc.contributor.authorKüçükaydın, Zehra
dc.contributor.authorBaşaran, Mustafa
dc.contributor.authorÜnlü, Yaşar
dc.contributor.authorBaşaran, Ahmet
dc.contributor.authorKurdoğlu, Mertihan
dc.date.accessioned2025-01-21T16:33:24Z
dc.date.available2025-01-21T16:33:24Z
dc.date.issued2023
dc.departmentKırıkkale Üniversitesi
dc.description.abstractBackground/aim: Laminin-1 and matrix metalloproteinase (MMP)-9 may play roles in the progression from benign to malignant endometrium, so we aimed to investigate their levels of expression in these tissues.Materials and methods: This case-control study was conducted at a tertiary care center between January 2014 and December 2016. Paraffin blocks of 50 specimens of benign endometrium with proliferative (n = 20), secretory (n = 11), and atrophic (n = 5) endometrium; simple endometrial hyperplasia without atypia (n = 12); and endometrial polyp (n = 2) histology and 49 specimens of malignant endometrium with endometrioid (n = 40), serous (n = 7), clear cell (n = 1), and undifferentiated (n = 1) types were immunostained with laminin-1 and MMP-9 antibodies and assessed for basement membrane continuity for laminin-1 and the percentage and intensity of MMP-9 expression in epithelial cytoplasm.Results: Laminin-1 continuity in the basement membrane was higher in benign (92%) compared to malignant (16.3%) endometrium (p < 0.0001) without any difference between the subgroups within each group (p > 0.05). All atrophic endometria and endometrial polyps and 23.5% of low grade endometrioid and none of the other endometrial cancers showed uninterrupted basement membrane staining with laminin-1. All cases in malignant endometrium expressed MMP-9 with either low or high immunoreactivity while none of the cases in benign endometrium showed a high staining with MMP-9 (p < 0.01). Proliferative and hyperplastic endometrium together with grade 1 endometrioid cancer expressed MMP-9 better than the atrophic endometrium (p < 0.05). The immunoreactivity with MMP-9 increased gradually from secretory to hyperplastic endometrium and serous carcinoma (p < 0.05). MMP-9 expression in all types of cancers except grade 1 endometrioid and clear cell compared to proliferative endometrium was significantly higher (p < 0.05) and increased from proliferative to grade 2 endometrioid, grade 3 endometrioid, serous and undifferentiated endometrial carcinoma.Conclusion: Gradual increments in MMP-9 expression and basement membrane laminin-1 discontinuity may indicate progression from normal to hyperplastic and to low-and high-grade cancerous endometrium.
dc.description.sponsorshipUniversity of Health Sciences, Konya Training and Research Hospital [21.01.2014/3]
dc.description.sponsorshipWe would like to thank Numan Duran for his contributions during the linguistic review of this article. This study was financially supported by University of Health Sciences, Konya Training and Research Hospital, Directorate of Scientific Research Projects (21.01.2014/3).
dc.identifier.doi10.55730/1300-0144.5568
dc.identifier.endpage159
dc.identifier.issn1300-0144
dc.identifier.issn1303-6165
dc.identifier.issue1
dc.identifier.pmid36945954
dc.identifier.scopus2-s2.0-85149152521
dc.identifier.scopusqualityQ1
dc.identifier.startpage149
dc.identifier.trdizinid1160113
dc.identifier.urihttps://doi.org/10.55730/1300-0144.5568
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay1160113
dc.identifier.urihttps://hdl.handle.net/20.500.12587/23794
dc.identifier.volume53
dc.identifier.wosWOS:000941667500018
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTubitak Scientific & Technological Research Council Turkey
dc.relation.ispartofTurkish Journal of Medical Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241229
dc.subjectEndometrium; endometrial neoplasms; endometrial hyperplasia; immunohistochemistry; laminin; matrix metalloproteinase 9
dc.titleExpression of laminin-1 and matrix metalloproteinase-9 in benign and malignant endometrium
dc.typeArticle

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