The Effects of Ketoprofen and Meloxicam on Bone Healing in Rat Model: A Comparative Dual Energy X-Ray Absorptiometry Study

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dc.contributor.authorKurum, Baris
dc.contributor.authorPekcan, Zeynep
dc.contributor.authorKarsli, Birkan
dc.contributor.authorKumandas, Ali
dc.contributor.authorElma, Ertugrul
dc.date.accessioned2020-06-25T18:06:32Z
dc.date.available2020-06-25T18:06:32Z
dc.date.issued2012
dc.departmentKırıkkale Üniversitesi
dc.descriptionKUMANDAS, ALI/0000-0002-7679-2126
dc.description.abstractPain control is a common clinical approach in trauma and postoperative care especially complicated orthopedic surgeries to ease the deleterious effects of pain. Various kinds of pain killers have been used, and nowadays nonsteroidal anti-inflammatory drugs (NSAIDs) are among the most commonly used drugs for pain control purposes. Prostaglandin-endoperoxide synthetase, also commonly called cyclooxygenase (COX), is one of the key enzymes in prostaglandin bio-synthesis. The COX enzymes have subgroups of enzymes, each of which suppresses different inflammatory mediators. These enzymes are involved in different functions, some of which are essential for continuity of physiological processes. Thus, NSAIDs are expected not to cause any change of functions of some enzymes while suppressing others. Among the COX enzymes, COX-1 is associated with gastrointestinal system functions and gastrointestinal mucosa while COX-2 is associated with inflammation and pain. Like most drugs, NSAIDs have known and possible side effects. In various studies related to NSAIDs, inhibitory effects of conventional NSAIDs with non-selective effects and specific COX-2 inhibitors on bone healing have been reported. In this study, the effects of ketoprofen and meloxicam on bone fracture healing induced in 24 adult male Wistar rats was studied by Dual Energy X-Ray Absorptiometry (DEXA). The results indicates that meloxicam inhibits the fracture healing to some degree.en_US
dc.description.sponsorshipScientific Research Project Coordination Unit of Kirikkale UniversityKirikkale Universityen_US
dc.description.sponsorshipThis research was supported by the Scientific Research Project Coordination Unit of Kirikkale Universityen_US
dc.identifier.citationKürüm B., Pekcan Z., Karslı B., Kumandaş A., Elma E. (2012). The effects of ketoprofen and meloxicam on bone healing in rat model: A comparative dual energy X-Ray absorptiometry study. Kafkas Üniversitesi Veteriner Fakültesi Dergisi, 18(4), 671 - 676.en_US
dc.identifier.endpage676en_US
dc.identifier.issn1300-6045
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-84861757666
dc.identifier.scopusqualityQ3
dc.identifier.startpage671en_US
dc.identifier.trdizinid131863
dc.identifier.urihttps://hdl.handle.net/20.500.12587/5236
dc.identifier.volume18en_US
dc.identifier.wosWOS:000305923500024
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.publisherKafkas Univ, Veteriner Fakultesi Dergisien_US
dc.relation.ispartofKafkas Universitesi Veteriner Fakultesi Dergisi
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCyclooxygenase inhibitors (COX)en_US
dc.subjectKetoprofenen_US
dc.subjectMeloxicamen_US
dc.subjectDual energy X-Ray Absorptiometry (DEXA)en_US
dc.subjectBone healingen_US
dc.subjectRaten_US
dc.titleThe Effects of Ketoprofen and Meloxicam on Bone Healing in Rat Model: A Comparative Dual Energy X-Ray Absorptiometry Studyen_US
dc.typeArticle

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