Periostin normalizes levels of cardiac markers in rats with experimental isoproterenol cardiotoxicity

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dc.contributor.authorDevrim, A. K.
dc.contributor.authorSozmen, M.
dc.contributor.authorDevrim, T.
dc.contributor.authorSudagidan, M.
dc.contributor.authorCinar, M.
dc.contributor.authorKabak, Y. B.
dc.date.accessioned2020-06-25T18:23:25Z
dc.date.available2020-06-25T18:23:25Z
dc.date.issued2017
dc.departmentKırıkkale Üniversitesi
dc.description.abstractBACKGROUND: Although the molecular mechanism of cardiac healing is not fully understood, myocardial infarction is one of the most usual diagnoses in hospitalized patients in industrialized nations while periostin has been recently suggested to have a potential in tissue repairing following myocardial ischemia. OBJECTIVES: To investigate the effects of periostin on the levels of selected cardiac parameters (cardiac troponin I and T, creatine kinase and creatine kinase isoenzyme-MB), antioxidant/lipid peroxidation parameters (superoxide dismutase, catalase, and malondialdehyde), hepatic parameters (alkaline phosphatase, lactate dehydrogenase, aspartate and alanine transaminases) as well as lipids (total cholesterol, triglyceride, high, low and very-low-density lipoproteins) in a rat model of isoproterenol - induced myocardial injury. METHODS: A total of 84 male rats were grouped into saline (Group I), periostin (Group II), isoproterenol (Group III) and isoproterenol+periostin (Group IV) groups (n = 21). Isoproterenol (85 mg/kg/day) and periostin groups were both injected intraperitoneally (1 mu g/kg). RESULTS: Our results revealed that periostin has a positive reducing effect on the levels of analysed parameters especially on cardiac troponins and creatine kinases on days 7 and 28 of the recovery period following the induced experimental heart damage in rats. CONCLUSION: It is concluded that periostin could have a potential to increase the rate of myocardial recovery after myocardial infarction (Tab. 5, Ref. 28). Text in PDF www.elis.sk.en_US
dc.description.sponsorshipScientific and Technological Research Council of Turkey (TUBITAK-TOVAG)Turkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [114O734]; TUBITAK-TOVAGTurkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK)en_US
dc.description.sponsorshipThis article is a part of the project funded by the Scientific and Technological Research Council of Turkey (TUBITAK-TOVAG; Project No.: 114O734). Authors' special thanks are extended to TUBITAK-TOVAG for financial support.en_US
dc.identifier.citationDevrim, A. K., Sozmen, M., Devrim, T., Sudagidan, M., Cinar, M., & Kabak, Y. B. (2017). Periostin normalizes levels of cardiac markers in rats with experimental isoproterenol cardiotoxicity. Bratislavske lekarske listy, 118(11), 705–709.en_US
dc.identifier.doi10.4149/BLL_2017_133
dc.identifier.endpage709en_US
dc.identifier.issn0006-9248
dc.identifier.issn1336-0345
dc.identifier.issue11en_US
dc.identifier.pmid29216729
dc.identifier.scopus2-s2.0-85037629643
dc.identifier.scopusqualityQ2
dc.identifier.startpage705en_US
dc.identifier.urihttps://doi.org/10.4149/BLL_2017_133
dc.identifier.urihttps://hdl.handle.net/20.500.12587/7095
dc.identifier.volume118en_US
dc.identifier.wosWOS:000418020700011
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherComenius Univen_US
dc.relation.ispartofBratislava Medical Journal-Bratislavske Lekarske Listy
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectperiostinen_US
dc.subjectisoproterenolen_US
dc.subjectacute myocardial infarctionen_US
dc.subjectcardiac troponinen_US
dc.subjectcreatine kinaseen_US
dc.titlePeriostin normalizes levels of cardiac markers in rats with experimental isoproterenol cardiotoxicityen_US
dc.typeArticle

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