Dual effects of melatonin on uterine myoelectrical activity of non-pregnant rats

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dc.contributor.authorŞimşek Y.
dc.contributor.authorParlakpinar H.
dc.contributor.authorTurhan U.
dc.contributor.authorTağluk M.E.
dc.contributor.authorAteş B.
dc.date.accessioned2020-06-25T15:17:29Z
dc.date.available2020-06-25T15:17:29Z
dc.date.issued2014
dc.departmentKırıkkale Üniversitesi
dc.description.abstractObjective: In this experimental study, we aimed to investigate the role of melatonin on uterine myoelectrical activity of non-pregnant rats. Material and Methods: Forty-six female rats were assigned to six groups: (1) control; (0.2 mL 0.9% NaCl was injected intravenously (IV), n=6); (2) melatonin applied as 0.4 mg/kg/IV (n=8); (3) melatonin applied as 4 mg/kg/IV (n=8); (4) single dose of oxytocin (100 mU/kg) injected IV (n=8); (5) melatonin (0.4 mg/kg) plus oxytocin (100 mU/kg) (n=8); and (6) melatonin (4 mg/kg) plus oxytocin (100 mU/kg) injected IV (n=8). Each rat underwent a laparotomy, and uterine myoelectrical signals were recorded. The mean spectrum, averaged over the spectral content of signals in each group, was compared. Results: Melatonin induced uterine myoelectrical activity in a dose-dependent manner. Treatment of melatonin after oxytocin suppressed the mean power of the signals. Serum melatonin concentrations were significantly higher in melatonin-treated rats. Conclusion: Melatonin itself at two different dose levels was found to be equally effective in stimulating the uterine electrical signals, although oxytocin-induced uterine electrical activity was suppressed by melatonin. These findings merit further investigations on the possible beneficial role of melatonin in the treatment of conditions associated with abnormal uterine activity. © 2014 by the Turkish-German Gynecological Education and Research Foundation.en_US
dc.identifier.citationŞimşek, Y., Parlakpınar, H., Turhan, U., Tuğluk, M. E., Ateş, B. (2014). Dual effects of melatonin on uterine myoelectrical activity of non-pregnant rats. Journal of the Turkish-German Gynecological Association, 15(2), 86 - 91.en_US
dc.identifier.doi10.5152/jtgga.2014.26932
dc.identifier.endpage91en_US
dc.identifier.issn13090399
dc.identifier.issue2en_US
dc.identifier.pmid24976773
dc.identifier.scopus2-s2.0-84902462886
dc.identifier.scopusqualityQ3
dc.identifier.startpage86en_US
dc.identifier.trdizinid159100
dc.identifier.urihttps://doi.org/10.5152/jtgga.2014.26932
dc.identifier.urihttps://hdl.handle.net/20.500.12587/2391
dc.identifier.volume15en_US
dc.identifier.wosWOS:000420674300006
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherAVES Ibrahim Karaen_US
dc.relation.ispartofJournal of the Turkish German Gynecology Association
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectElectrical stimulationen_US
dc.subjectMelatoninen_US
dc.subjectOxytocinen_US
dc.subjectUterine contractionen_US
dc.titleDual effects of melatonin on uterine myoelectrical activity of non-pregnant ratsen_US
dc.typeArticle

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