Effects of TVE application during 70% hepatectomy on regeneration capacity of rats

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dc.contributor.authorTopaloğlu, Serdar
dc.contributor.authorİzci, Erdal
dc.contributor.authorÖzel, Hakan
dc.contributor.authorTopaloğlu, Eda
dc.contributor.authorAvşar, Fatih M.
dc.contributor.authorSaygun, Oral
dc.contributor.authorHengirmen, Süleyman
dc.date.accessioned2020-06-25T17:40:45Z
dc.date.available2020-06-25T17:40:45Z
dc.date.issued2005
dc.departmentKırıkkale Üniversitesi
dc.description.abstractBackground For adequate control of excess bleeding during liver resection, total vascular exclusion (TVE) is preferred by surgeons, especially when the tumor is located in the posterior liver lobes or near the cava. To the authors' knowledge, the effects of TVE technique on the postoperative liver regeneration process have not thus far been evaluated yet in the literature. This study was planned to compare the effects of liver resections performed either with portal pedicle clamping or with TVE on the regeneration process. Materials and methods. Seventy percent hepatectomy was performed with portal pedicle clamping (n = 10, Group A) or with TVE (n = 10, Group B) in rats. At 48 h after resection, sampling was performed for the measurement of serum transaminase, alkaline phosphatase (ALP), tissue malondialdehyde (AIDA), and glutathione (GSH) levels. Liver regeneration rate, proliferating cell nuclear antigen (PCNA) labeling, and mitotic indices were also evaluated. Results. Liver injury determinants (serum transaminases, ALP, and tissue MDA levels) were found significantly higher in group B than in group A. Liver regeneration rate, liver GSH levels, PCNA labeling index, and mitotic index were significantly lower in group B than in group A. Conclusions. The injury during TVE seems to be greater than during resection with portal pedicle clamping. The negative effect of this oxidative damage may influence the regenerative capacity of the remnant liver tissue. (c) 2004 Elsevier Inc. All rights reserved.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1016/j.jss.2004.09.012
dc.identifier.endpage145en_US
dc.identifier.issn0022-4804
dc.identifier.issue1en_US
dc.identifier.pmid15734492
dc.identifier.scopus2-s2.0-13944283017
dc.identifier.scopusqualityQ1
dc.identifier.startpage139en_US
dc.identifier.urihttps://doi.org/10.1016/j.jss.2004.09.012
dc.identifier.urihttps://hdl.handle.net/20.500.12587/3539
dc.identifier.volume124en_US
dc.identifier.wosWOS:000227650100022
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherAcademic Press Inc Elsevier Scienceen_US
dc.relation.ispartofJournal Of Surgical Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectliver resectionen_US
dc.subjecttotal vascular exclusionen_US
dc.subjectregenerationen_US
dc.titleEffects of TVE application during 70% hepatectomy on regeneration capacity of ratsen_US
dc.typeArticle

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