Perception of dyspnea during exacerbation and histamine-related bronchoconstriction in patients with asthma

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dc.contributor.authorEkici, Mehmet
dc.contributor.authorEkici, Aydanur
dc.contributor.authorKara, Türkan
dc.contributor.authorKeleş, Hatice
dc.contributor.authorKarlıdağ, Ali
dc.contributor.authorAltunkaya, Volkan
dc.contributor.authorBulcun, Emel
dc.date.accessioned2020-06-25T17:43:33Z
dc.date.available2020-06-25T17:43:33Z
dc.date.issued2006
dc.description.abstractBackground: Numerous studies have been performed concerning the perception of dyspnea during changes in airway caliber provoked in the laboratory setting, but studies of asthma exacerbation are scarce. Objective: To investigate whether the perception of dyspnea during histamine-induced bronchoconstriction might be used to identify patients with asthma who sense dyspnea poorly during exacerbation. Methods: The perception of dyspnea in 50 patients (45 female, 5 male) with asthma was evaluated at admission with exacerbation and during a stable period. Perceived intensity of dyspnea was estimated using a modified Borg scale. The perception of dyspnea in the stable period 4 to 6 weeks after exacerbation was measured with the histamine challenge test. Perception parameters were defined as the change in Borg score divided by the change in forced expiratory volume in 1 second (FEV1) as a percentage of the baseline FEV1 (Delta Borg/Delta FEV1) and as the Borg score at 20% decrease (PS20Histamine) or increase (PS20Exacerbation) in FEV1. Results: The perception of dyspnea during asthma exacerbation was unrelated to the perception of dyspnea during histamine-induced bronchoconstriction (for Delta Borg/Delta FEV1, beta = .08, P = .50; for PS20, beta = -.11, P = .40). The K value for the agreement of poor perceivers at exacerbation and during the stable period was -0.21 (P = .10). However, the intensity of dyspnea caused by histamine-induced bronchoconstriction was lower than that caused by asthma exacerbation (PS20: 1.6 +/- 1.1 vs 2.8 +/- 2.5. respectively. P = .004; Delta Borg/Delta FEV1: 0.08 +/- 0.05 vs 0.21 +/- 0.28, respectively, P = .001). Conclusion: The perception of dyspnea during asthma exacerbation is not correlated with the perception of dyspnea during histamine-induced bronchoconstriction. Therefore, the perception of dyspnea during histamine-induced bronchoconstriction cannot be used to identify the asthmatic patients who perceive dyspnea poorly.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1016/S1081-1206(10)61069-1
dc.identifier.endpage712en_US
dc.identifier.issn1081-1206
dc.identifier.issn1534-4436
dc.identifier.issue5en_US
dc.identifier.pmid16729784
dc.identifier.scopus2-s2.0-33646770660
dc.identifier.scopusqualityQ1
dc.identifier.startpage707en_US
dc.identifier.urihttps://doi.org10.1016/S1081-1206(10)61069-1
dc.identifier.urihttps://hdl.handle.net/20.500.12587/3790
dc.identifier.volume96en_US
dc.identifier.wosWOS:000237857400014
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier Science Incen_US
dc.relation.ispartofAnnals Of Allergy Asthma & Immunology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.titlePerception of dyspnea during exacerbation and histamine-related bronchoconstriction in patients with asthmaen_US
dc.typeArticle

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