Effect of iloprost on erythrocyte deformability in rat's lower extremity undergoing an ischemia reperfusion injury
Yükleniyor...
Tarih
2013
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Comenius Univ
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Aim: Ischemia reperfusion injury (I/R) in lower extremity is a frequent and important clinical phenomenon. The protective effect of iloprost on local and distant organ injury due to I/R has been well documented but its effect on erythrocyte deformability needs further investigation. Our aim was to investigate the effect of iloprost on erythrocyte deformability in the infrarenal aorta of rats undergoing I/R. Materials and methods: Our study was conducted with 18 Wistar albino rats. Rats were divided into the 3 groups; the randomized control group (group C; n=6), I/R group without iloprost (group I/R; n=6) and I/R group with iloprost 10 mcg.kg(-1), 30 min infusion (group I/R-I; n=6). Packs of erythrocytes were prepared from heparinized blood samples and deformability measurements were done. Results: The comparisons of the control and I/R-I groups revealed similar results (p=0.951). The values of the IR group were significantly higher than those of the control and IR-I groups (p=0.006, p=0.011, respectively). Conclusion: In our study, we detected the unfavourable effects of I/R on erythrocyte deformability, which may lead to disturbance in blood flow and hence tissue perfusion in the infrarenal rat aorta. We also found that Iloprost had beneficial effects by reversing the undesirable effects of I/R (Fig. 1, Ref. 15). Full Text in PDF www.elis.sk.
Açıklama
Arslan, Mustafa/0000-0003-4882-5063
Anahtar Kelimeler
erythrocyte deformability, ischemia reperfusion, ilioprost, rat
Kaynak
Bratislava Medical Journal-Bratislavske Lekarske Listy
WoS Q Değeri
Q4
Scopus Q Değeri
Q2
Cilt
114
Sayı
4
Künye
Arslan, M., Donmez, T., Erer, D., Tatar, T., Comu, F. M., & Alkan, M. (2013). Effect of iloprost on erythrocyte deformability in rat's lower extremity undergoing an ischemia reperfusion injury. Bratislavske lekarske listy, 114(4), 189–191.
