Effect of iloprost on erythrocyte deformability in rat's lower extremity undergoing an ischemia reperfusion injury

Basit Öğe Kaydı
dc.contributor.authorArslan, M.
dc.contributor.authorDonmez, T.
dc.contributor.authorErer, D.
dc.contributor.authorTatar, T.
dc.contributor.authorComu, F. M.
dc.contributor.authorAlkan, M.
dc.date.accessioned2020-06-25T18:07:43Z
dc.date.available2020-06-25T18:07:43Z
dc.date.issued2013
dc.departmentKırıkkale Üniversitesi
dc.descriptionArslan, Mustafa/0000-0003-4882-5063
dc.description.abstractAim: Ischemia reperfusion injury (I/R) in lower extremity is a frequent and important clinical phenomenon. The protective effect of iloprost on local and distant organ injury due to I/R has been well documented but its effect on erythrocyte deformability needs further investigation. Our aim was to investigate the effect of iloprost on erythrocyte deformability in the infrarenal aorta of rats undergoing I/R. Materials and methods: Our study was conducted with 18 Wistar albino rats. Rats were divided into the 3 groups; the randomized control group (group C; n=6), I/R group without iloprost (group I/R; n=6) and I/R group with iloprost 10 mcg.kg(-1), 30 min infusion (group I/R-I; n=6). Packs of erythrocytes were prepared from heparinized blood samples and deformability measurements were done. Results: The comparisons of the control and I/R-I groups revealed similar results (p=0.951). The values of the IR group were significantly higher than those of the control and IR-I groups (p=0.006, p=0.011, respectively). Conclusion: In our study, we detected the unfavourable effects of I/R on erythrocyte deformability, which may lead to disturbance in blood flow and hence tissue perfusion in the infrarenal rat aorta. We also found that Iloprost had beneficial effects by reversing the undesirable effects of I/R (Fig. 1, Ref. 15). Full Text in PDF www.elis.sk.en_US
dc.identifier.citationArslan, M., Donmez, T., Erer, D., Tatar, T., Comu, F. M., & Alkan, M. (2013). Effect of iloprost on erythrocyte deformability in rat's lower extremity undergoing an ischemia reperfusion injury. Bratislavske lekarske listy, 114(4), 189–191.en_US
dc.identifier.doi10.4149/BLL_2013_040
dc.identifier.endpage191en_US
dc.identifier.issn0006-9248
dc.identifier.issue4en_US
dc.identifier.pmid23514550
dc.identifier.scopus2-s2.0-84875684508
dc.identifier.scopusqualityQ2
dc.identifier.startpage189en_US
dc.identifier.urihttps://doi.org/10.4149/BLL_2013_040
dc.identifier.urihttps://hdl.handle.net/20.500.12587/5647
dc.identifier.volume114en_US
dc.identifier.wosWOS:000318058700002
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherComenius Univen_US
dc.relation.ispartofBratislava Medical Journal-Bratislavske Lekarske Listy
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjecterythrocyte deformabilityen_US
dc.subjectischemia reperfusionen_US
dc.subjectilioprosten_US
dc.subjectraten_US
dc.titleEffect of iloprost on erythrocyte deformability in rat's lower extremity undergoing an ischemia reperfusion injuryen_US
dc.typeArticle

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim
İsim:
Effect of iloprost on erythrocyte deformability in rat's lower extremity undergoing an ischemia reperfusion injury.pdf
Boyut:
302.6 KB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin/Full Text
İndir

Koleksiyon

WOS İndeksli Yayınlar Koleksiyonu
Makale Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu