Apoptotic and necrotic effects of carboxylated quercetin/polyethylenimine complex on HeLa cells

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dc.contributor.authorUlug, Murat
dc.contributor.authorTurk, Mustafa
dc.contributor.authorOguztuzun, Serpil
dc.contributor.authorMenemen, Yusuf
dc.contributor.authorKahraman, Gulten
dc.date.accessioned2020-06-25T17:51:44Z
dc.date.available2020-06-25T17:51:44Z
dc.date.issued2011
dc.departmentKırıkkale Üniversitesi
dc.description.abstractThe effects of quercetin (Q), carboxylated quercetin (CQ) and carboxylated quercetin/polyethylenimine (CQ/PEI) complex on HeLa cell cultures were investigated. Firstly, carboxylated quercetin was acquired through hydroxyl groups of quercetin, using chloroacetic acid. The complex of CQ/PEI was acquired by electron cooperation path over polietilenimine amine groups and quercetin carboxyl groups. CQ and CQ/PEI obtained were characterised by FTIR and H-1-NMR methods. Cytotoxicity was determined by MTT assay. Apoptotic and necrotic indexes were obtained by immunocytochemical staining with the M30 antibodies and double staining and double staining, respectively. It was determined that quercetin caused lower rates of necrosis and apoptosis on HeLa cells by itself, but CQ/PEI complex resulted in high levels. As a result, it was observed that transition of quercetin to HeLa via binding it to polyethylenimine increased its anticarcinogenic effects.en_US
dc.description.sponsorshipKirikkale University Science Research FoundationKirikkale University [2007/70]; Kirikkale University of TurkeyKirikkale Universityen_US
dc.description.sponsorshipThis work was supported by Kirikkale University Science Research Foundation Project (number; 2007/70) of Kirikkale University of Turkey.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.endpage902en_US
dc.identifier.issn1996-0816
dc.identifier.issue7en_US
dc.identifier.scopus2-s2.0-80051653170
dc.identifier.scopusqualityN/A
dc.identifier.startpage894en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12587/4976
dc.identifier.volume5en_US
dc.identifier.wosWOS:000295799500013
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherAcademic Journalsen_US
dc.relation.ispartofAfrican Journal Of Pharmacy And Pharmacology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectQuercetinen_US
dc.subjectHeLaen_US
dc.subjectcanceren_US
dc.subjectapoptosisen_US
dc.subjectnecrosisen_US
dc.subjectcytotoxicityen_US
dc.titleApoptotic and necrotic effects of carboxylated quercetin/polyethylenimine complex on HeLa cellsen_US
dc.typeArticle

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