Relationship between seropositivity of Encephalitozoon cuniculi and renal biochemical markers in clinically healthy rabbits

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dc.contributor.authorOzkan, Ozcan
dc.contributor.authorYucesan, Banucicek
dc.contributor.authorPekkaya, Selcuk
dc.contributor.authorAlcigir, Mehmet Eray
dc.contributor.authorGurcan, Ismayil Safa
dc.date.accessioned2020-06-25T18:34:32Z
dc.date.available2020-06-25T18:34:32Z
dc.date.issued2019
dc.departmentKırıkkale Üniversitesi
dc.description.abstractEncephalitozoon cuniculi can cause latent disease, especially in lagomorphs and many wild and domestic animals in various countries. This infection is important for veterinary and public health because it is caused by a potentially zoonotic and opportunistic pathogen. The aim of this study was to investigate the relationship between seropositivity of E. cuniculi and renal function markers, which may be useful in predicting the disease in clinically healthy rabbits. In this study, the seropositivity of E. cuniculi infection in clinically healthy rabbits was determined, and necropsy fmdings were evaluated along with the results of renal function tests. In a laboratory rabbit breeding facility, enzyme-linked immunosorbent assay (ELISA) tests showed that 48 (49.5%) of 97 rabbits were seropositive against E. cuniculi. Blood urea nitrogen (BUN) and creatinine levels were significantly elevated in seropositive animals. Two seropositive rabbits were necropsied to confirm the infection. According to histopathological findings in the kidney, degenerative changes and E. cuniculi spores were identified in the tubule epithelia. Serum creatinine (p<0.001) and BUN (p<0.01) levels were found to have a statistically significant relationship with the serological status of rabbits. Serological and histopathological methods are not routinely used in rabbits to diagnose E. cuniculi infection. The kidneys were one of the most affected organs in encephalitozoonosis in rabbits. As revealed in this study, the testing blood urea nitrogen and creatinine levels would be useful for the evaluation of general health status and renal function of the seropositive rabbits, and clinical interpretation as well.en_US
dc.identifier.citationÖzkan Ö., Yücesan B., Pekkaya S., Alçığır M. E., Gürcan İ. S. (2019). Relationship between seropositivity of Encephalitozoon cuniculi and renal biochemical markers in clinically healthy rabbits. Ankara Üniversitesi Veteriner Fakültesi Dergisi, 66(2), 197 - 204.en_US
dc.identifier.doi10.33988/auvfd.433457
dc.identifier.endpage204en_US
dc.identifier.issn1300-0861
dc.identifier.issn1308-2817
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-85077046115
dc.identifier.scopusqualityQ3
dc.identifier.startpage197en_US
dc.identifier.trdizinid315228
dc.identifier.urihttps://doi.org/10.33988/auvfd.433457
dc.identifier.urihttps://hdl.handle.net/20.500.12587/7946
dc.identifier.volume66en_US
dc.identifier.wosWOS:000471803700012
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.publisherAnkara Univ Pressen_US
dc.relation.ispartofAnkara Universitesi Veteriner Fakultesi Dergisi
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectBiochemical markersen_US
dc.subjectEncephalitozoon cuniculien_US
dc.subjectrabbiten_US
dc.subjectrenal functionen_US
dc.titleRelationship between seropositivity of Encephalitozoon cuniculi and renal biochemical markers in clinically healthy rabbitsen_US
dc.typeArticle

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