Azithromycin therapy of papillomatosis in dogs: a prospective, randomized, double-blinded, placebo-controlled clinical trial

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dc.contributor.authorYagci, Bugrahan Bekir
dc.contributor.authorUral, Kerem
dc.contributor.authorOcal, Naci
dc.contributor.authorHaydardedeoglu, Ali Evren
dc.date.accessioned2020-06-25T17:44:28Z
dc.date.available2020-06-25T17:44:28Z
dc.date.issued2008
dc.departmentKırıkkale Üniversitesi
dc.description.abstractAzithromycin, an azalide subclass macrolide antibiotic, is an effective, well-tolerated and safe therapeutic option for treatment of papillomatosis in humans. This study reports the clinical and histopathological results from a prospective, randomized, double-blinded, placebo-controlled trial of 17 dogs of various breeds with diagnosis of oral (n = 12) and cutaneous papillomatosis (n = 5) treated with azithromycin. Papillomas appeared as whitish, verrucous, hyperkeratotic papules 1-2.7 mm in size. The cases were randomly assigned to azithromycin (n = 10) and placebo treatment groups (n = 7). Both owners and investigators were blinded to the allocation to the groups. Azithromycin (10 mg/kg) was administered per os every 24 h for 10 days. Clinical evaluations were done by the same investigator throughout the trial. Azithromycin treatment significantly decreased clinical scores (P < 0.001), whereas there was no change seen in the placebo group. In the azithromycin treatment group, skin lesions disappeared in 10-15 days. One case in the placebo had spontaneous regression of its papillomas by day 41, but lesions were still evident at day 50 in the remaining six cases. There was no recurrence of papillomatosis in the azithromycin treated dogs (follow up 8 months). No adverse effects were seen in either group. In conclusion, azithromycin appears to be a safe and effective treatment for canine papillomatosis.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1111/j.1365-3164.2008.00674.x
dc.identifier.endpage198en_US
dc.identifier.issn0959-4493
dc.identifier.issue4en_US
dc.identifier.pmid18494759
dc.identifier.scopus2-s2.0-58149388812
dc.identifier.scopusqualityQ1
dc.identifier.startpage194en_US
dc.identifier.urihttps://doi.org/10.1111/j.1365-3164.2008.00674.x
dc.identifier.urihttps://hdl.handle.net/20.500.12587/4120
dc.identifier.volume19en_US
dc.identifier.wosWOS:000257699200002
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWiley-Blackwellen_US
dc.relation.ispartofVeterinary Dermatology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.titleAzithromycin therapy of papillomatosis in dogs: a prospective, randomized, double-blinded, placebo-controlled clinical trialen_US
dc.typeArticle

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