Manic symptoms probably associated with short-term low-dose quetiapine use

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dc.contributor.authorErberk-Ozen, Nurper
dc.date.accessioned2020-06-25T17:48:02Z
dc.date.available2020-06-25T17:48:02Z
dc.date.issued2008
dc.description.abstractNowadays, there is a widespread use of atypical (second-generation) antipsychotics as an adjunct pharmacotherapy in psychiatry clinics, especially at lower doses in several diagnoses. Here, 2 cases are reported where patients with diagnosed schizophrenia displayed manic symptoms on quetiapine 100 mg/d. The cases presented here had no history of mood disorders. It is discussed that the mania/hypomania may be associated with quetiapine treatment and defined as an adverse effect. Manic symptoms may be a 'probable adverse effect' according to the Naranjo adverse drug reactions probability scale, with a score of 6 points in both our cases. Several studies have suggested that quetiapine-induced mania/hypomania may be associated with frontal dopamine release via serotonin 5HT2A receptor blockade. Hence, clinicians should monitor the mood alterations of patients carefully during the atypical antipsychotic treatment. This is also the conclusion of our study as the patients may be slow metabolisers of CYP450-3A4, as suggested by their previous side effects on different antipsychotics.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1007/s12325-008-0003-4
dc.identifier.endpage57en_US
dc.identifier.issn0741-238X
dc.identifier.issn1865-8652
dc.identifier.issue1en_US
dc.identifier.pmid18224291
dc.identifier.scopus2-s2.0-58749115771
dc.identifier.scopusqualityQ1
dc.identifier.startpage53en_US
dc.identifier.urihttps://doi.org10.1007/s12325-008-0003-4
dc.identifier.urihttps://hdl.handle.net/20.500.12587/4249
dc.identifier.volume25en_US
dc.identifier.wosWOS:000255873200008
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringeren_US
dc.relation.ispartofAdvances In Therapy
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectadverse effectsen_US
dc.subjecthypomaniaen_US
dc.subjectmaniaen_US
dc.subjectpsychiatryen_US
dc.subjectquetiapineen_US
dc.subjectschizophreniaen_US
dc.titleManic symptoms probably associated with short-term low-dose quetiapine useen_US
dc.typeArticle

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