Synthesis, characterization and modification of Gum Arabic microgels for hemocompatibility and antimicrobial studies

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dc.contributor.authorFarooq, Muhammad
dc.contributor.authorSagbas, Selin
dc.contributor.authorSahiner, Mehtap
dc.contributor.authorSiddiq, Mohammad
dc.contributor.authorTurk, Mustafa
dc.contributor.authorAktas, Nahit
dc.contributor.authorSahiner, Nurettin
dc.date.accessioned2020-06-25T18:23:14Z
dc.date.available2020-06-25T18:23:14Z
dc.date.issued2017
dc.departmentKırıkkale Üniversitesi
dc.descriptionSagbas Suner, Selin/0000-0002-3524-0675; Sahiner, Nurettin/0000-0003-0120-530X; Aktas, Nahit/0000-0001-9341-607X
dc.description.abstractGum Arabic (GA) microgels were successfully prepared via reverse micellization method with high yield (78.5 +/- 5.0%) in 5-100 mu m size range using divinyl sulfone (DVS) as a crosslinker. The GA microgels were degraded hydrolytically 22.8 +/- 3.5% at pH 1 in 20 days, whereas no degradation was observed at pH 7.4 and pH 9 at 37 degrees C. By using diethylenetriamine (DETA), and taurine (TA) as chemical modifying agents, GA microgels were chemically modified as GA-DETA and GA-TA, and the zeta potential values of 5.2 +/- 4.1 and -24.8 +/- 1.3 mV were measured, respectively in comparison to -27.3 +/- 4.2 mV for GA. Moreover, blood compatibility of GA, GA-TA, and GA-DETA microgels was tested via in vitro protein adsorption, % hemolysis ratio, and blood clotting index. All the microgels were hemocompatible with% hemolysis ratio between 0.23 to 2.05, and the GA microgels were found to be highly compatible with a blood clotting index of 81 +/- 40. The biocompatibility of GA, GA-DETA and GA-Taurine microgels against L929 fibroblast cells also revealed 84.4, 89.1, and 67.0% cell viability, respectively, at 25.0 mu g/mL concentration, suggesting great potential in vivo biomedical applications up to this concentration. In addition, 5 and 10 mgImL minimum inhibition concentrations of protonated GA-DETA microgels (GA-DETA-HCl) were determined against E. coli and S. aureus, respectively. (C) 2016 Elsevier Ltd. All rights reserved.en_US
dc.description.sponsorshipScientific and Technological Research Council of Turkey (TUBITAK)Turkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [TUBITAK 2216]en_US
dc.description.sponsorshipM. Farooq is grateful to The Scientific and Technological Research Council of Turkey (TUBITAK) for the support under the TUBITAK 2216 research fellowship program.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1016/j.carbpol.2016.09.052
dc.identifier.endpage389en_US
dc.identifier.issn0144-8617
dc.identifier.issn1879-1344
dc.identifier.pmid27842837
dc.identifier.scopus2-s2.0-84988351598
dc.identifier.scopusqualityQ1
dc.identifier.startpage380en_US
dc.identifier.urihttps://doi.org/10.1016/j.carbpol.2016.09.052
dc.identifier.urihttps://hdl.handle.net/20.500.12587/7047
dc.identifier.volume156en_US
dc.identifier.wosWOS:000388110900043
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier Sci Ltden_US
dc.relation.ispartofCarbohydrate Polymers
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectGum Arabic microgels/nanogelsen_US
dc.subjectModifiable GA particleen_US
dc.subjectDegradable/biocompatible GA microgelen_US
dc.subjectAntimicrobial GA microgelen_US
dc.titleSynthesis, characterization and modification of Gum Arabic microgels for hemocompatibility and antimicrobial studiesen_US
dc.typeArticle

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