Epidural volume expansion: is there a ceiling effect?

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dc.contributor.authorDoğancı, Nur
dc.contributor.authorApan, Alparslan
dc.contributor.authorTekin, Öznur
dc.contributor.authorKaymak, C.
dc.date.accessioned2020-06-25T17:51:15Z
dc.date.available2020-06-25T17:51:15Z
dc.date.issued2010
dc.departmentKırıkkale Üniversitesi
dc.description.abstractAim. The optimal volume of epidural saline administration on spinal anesthesia is not clear. The aim of this study was therefore to evaluate the block characteristics of 5, 10, 15, and 20 mL epidural saline after spinal anesthesia. Methods. This prospective, randomized double-blind study was conducted in the operation room setting of a university hospital. Seventy-five healthy adult patients electively undergoing limb surgery under regional anesthesia were investigated. Spinal anesthesia was performed, and plain bupivacaine (10 mg) was administered within one minute using combined spinal and epidural anesthesia. Epidural catheters were introduced, and patients were allocated to one of five groups to receive 0, 5, 10, 15 or 20 mL saline through the catheter (N=15 in each group). The patient was assessed every minute for motor and sensory block levels until a maximum level was reached. In addition, the patient was assessed thereafter in five-minute intervals using Bromage's scale for motor block and pinprick/cold sensation for sensory block. Results. The maximum level of spinal analgesia was significantly lower in the control group compared to the saline treatment groups, but there was no significant difference between the epidural saline groups. The periods for motor block resolution were the same. The duration of analgesia was significantly longer in patients receiving 15 mL, saline compared to other groups. The time to regression to the L1 level was significantly longer with 15- and 20-mL treatment groups compared to the 5- and 10-mL groups. Conclusion. The present results indicate that a ceiling effect was observed on the duration of spinal analgesia using plain bupivacaine with epidural saline loading (maximum- 15 mL). (Minerva Anestesiol 2010,76:334-9)en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.endpage339en_US
dc.identifier.issn0375-9393
dc.identifier.issn1827-1596
dc.identifier.issue5en_US
dc.identifier.pmid20395895
dc.identifier.scopus2-s2.0-77954669639
dc.identifier.scopusqualityQ2
dc.identifier.startpage334en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12587/4755
dc.identifier.volume76en_US
dc.identifier.wosWOS:000277446100007
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherEdizioni Minerva Medicaen_US
dc.relation.ispartofMinerva Anestesiologica
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAnesthesia, conductionen_US
dc.subjectInjections, epiduralen_US
dc.subjectSaline solution, hypertonicen_US
dc.titleEpidural volume expansion: is there a ceiling effect?en_US
dc.typeArticle

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