Adjuvant chemotherapy outcomes in patients over 65 years with early stage colorectal carcinoma
Yükleniyor...
Tarih
2014
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Imprimatur Publications
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Purpose: To evaluate the clinicopathological characteristics and the outcomes of adjuvant chemotherapy of patients with colorectal cancer aged >= 65 years. Methods: Between March 2003 and December 2010, the medical files of 562.colorectal cancer patients >= 65 years of age who were under follow-up in Ankara Numune Educational Hospital, Department of Medical Oncology, were retrospectively analyzed. Only 210 patients with non-metastatic disease at the time of diagnosis and those who had undergone surgical resection were included in the study. Results: The patient median age was 71 years (range 65-87). Of the patients, 115 (54.8%) were males and 95 (45.2%) females. The most common involvement site was the rectum (41.4%), followed by sigmoid colon (21.9%). According to the TNM staging, 12.4% patients had stage I, 48.6% stage II, and 39% stage III disease. At the time of diagnosis 19 patients (9%) had ECOG PS 0, 112 (53.3%) ECOG PS 1, 61(29%) ECOG PS 2, and 16 (7.7%) ECOG PS 3. Of the patients, 141 (66.5%) were administered adjuvant chemotherapy, whereas 69 patients (33%) were not. Thirty nine (18.6%) patients with adjuvant chemotherapy received fluorouracil/folinic acid (PUPA) weekly, 59 (28%) received FUFA infusion, and 43 (21%) received oxaliplatin, folinic acid and 5-fluorouracil (FOLFOX-4) regimen. The median follow-up was 27 months (range 1-116). Disease free survival (DFS) was not reached during the follow-up period. The estimated overall survival (OS) was 68.8 months (range 48.5-73.0). Sixty six (31%) patients died during follow-up. Conclusion: Elderly patients with high risk for recurrence of colorectal cancer must receive adjuvant chemotherapy after curative surgery. Infusional PUPA seems more effective than other regimens.
Açıklama
Aksoy, Sercan/0000-0003-4984-1049;
Anahtar Kelimeler
adjuvant chemotherapy, colorectal cancer, elderly patients, FOLFOX-4, FUFA
Kaynak
Journal Of Buon
WoS Q Değeri
Q4
Scopus Q Değeri
N/A
Cilt
19
Sayı
4
Künye
Civelek, B., Aksoy, S., Sendur, M. A., Yazici, O., Kanmaz, H., Kos, F. T., Yildirim, N., Uncu, D., & Zengin, N. (2014). Adjuvant chemotherapy outcomes in patients over 65 years with early stage colorectal carcinoma. Journal of B.U.ON. : official journal of the Balkan Union of Oncology, 19(4), 906–912.
