The anticancer activity of doxorubicin-loaded levan-functionalized gold nanoparticles synthesized by laser ablation

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Tarih

2022

Dergi Başlığı

Dergi ISSN

Cilt Başlığı

Yayıncı

Elsevier

Erişim Hakkı

info:eu-repo/semantics/closedAccess

Özet

Here, gold nanoparticles (AuNPs) were synthesized upon exposure to nano-pulsed Nd-YAG laser irradiation in de-ionized water (PLAL) and functionalized with levan polysaccharide for assessing the anticancer efficacy of doxorubicin (DOX)-conjugated levan-capped AuNPs complexes to MCF-7 breast cancer cells. According to the physicochemical test results, the increments in levan amount enhanced the colloidal stability and the drug encapsulation efficiency (DEE) significantly. For the 10L-AuNP group having the highest levan amount (10 mg/ mL levan), DEE was calculated as 92.21 +/- 0.56%. The lean levan, uncapped AuNPs, and 10L-AuNP were found non-cytotoxic (> 80% cell viability) in the studied concentrations with 48 h MTT assays. At higher DOX loadings (25, 50, and 100 mu g/mL) of 10L-AuNP, the cell viability reduced significantly compared to free DOX. Overall, these nanoparticle complexes could be proposed as potent drug delivery vehicles for cancer drugs such as DOX, as well as other drugs in the prospective studies.

Açıklama

Anahtar Kelimeler

Levan; Gold nanoparticle; Doxorubicin; Nano-pulsed laser; Cytotoxicity; Anticancer activity

Kaynak

International Journal of Biological Macromolecules

WoS Q Değeri

Q1

Scopus Q Değeri

Q1

Cilt

196

Sayı

Künye