The anticancer activity of doxorubicin-loaded levan-functionalized gold nanoparticles synthesized by laser ablation

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dc.contributor.authorAkturk, Omer
dc.date.accessioned2025-01-21T16:44:52Z
dc.date.available2025-01-21T16:44:52Z
dc.date.issued2022
dc.departmentKırıkkale Üniversitesi
dc.description.abstractHere, gold nanoparticles (AuNPs) were synthesized upon exposure to nano-pulsed Nd-YAG laser irradiation in de-ionized water (PLAL) and functionalized with levan polysaccharide for assessing the anticancer efficacy of doxorubicin (DOX)-conjugated levan-capped AuNPs complexes to MCF-7 breast cancer cells. According to the physicochemical test results, the increments in levan amount enhanced the colloidal stability and the drug encapsulation efficiency (DEE) significantly. For the 10L-AuNP group having the highest levan amount (10 mg/ mL levan), DEE was calculated as 92.21 +/- 0.56%. The lean levan, uncapped AuNPs, and 10L-AuNP were found non-cytotoxic (> 80% cell viability) in the studied concentrations with 48 h MTT assays. At higher DOX loadings (25, 50, and 100 mu g/mL) of 10L-AuNP, the cell viability reduced significantly compared to free DOX. Overall, these nanoparticle complexes could be proposed as potent drug delivery vehicles for cancer drugs such as DOX, as well as other drugs in the prospective studies.
dc.description.sponsorshipScientific Research Projects Coordination Unit of Kirikkale University [2017/017]
dc.description.sponsorshiphe Scientific Research Projects Coordination Unit of Kirikkale University (No: 2017/017) supported this study. Thanks to the Scientific and Technological Researches Application and Investigation Center of Kirikkale University (KUBTUAM) in Turkey for providing the cell cul-ture facilities. The following analyses were also carried out in KUB-TUAM: Zetasizer and FTIR. 1H NMR, 13C NMR Spectroscopy, CTEM, and XPS analyses were conducted at the Central Laboratory of Middle East Technical University (METU) in Turkey.
dc.identifier.doi10.1016/j.ijbiomac.2021.12.030
dc.identifier.endpage85
dc.identifier.issn0141-8130
dc.identifier.issn1879-0003
dc.identifier.pmid34923000
dc.identifier.scopus2-s2.0-85121745023
dc.identifier.scopusqualityQ1
dc.identifier.startpage72
dc.identifier.urihttps://doi.org/10.1016/j.ijbiomac.2021.12.030
dc.identifier.urihttps://hdl.handle.net/20.500.12587/25538
dc.identifier.volume196
dc.identifier.wosWOS:000781623100006
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier
dc.relation.ispartofInternational Journal of Biological Macromolecules
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241229
dc.subjectLevan; Gold nanoparticle; Doxorubicin; Nano-pulsed laser; Cytotoxicity; Anticancer activity
dc.titleThe anticancer activity of doxorubicin-loaded levan-functionalized gold nanoparticles synthesized by laser ablation
dc.typeArticle

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