What is the role of bosentan in healing of femur fractures in a rat model?

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dc.contributor.authorAydin, Ali
dc.contributor.authorHalici, Zekai
dc.contributor.authorAkpinar, Erol
dc.contributor.authorAksakal, A. Murat
dc.contributor.authorSaritemur, Murat
dc.contributor.authorYayla, Muhammed
dc.contributor.authorKarcioglu, S. Sena
dc.date.accessioned2020-06-25T18:12:58Z
dc.date.available2020-06-25T18:12:58Z
dc.date.issued2015
dc.departmentKırıkkale Üniversitesi
dc.descriptionATMACA, HASAN TARIK/0000-0001-8379-4114; Yayla, Muhammed/0000-0002-0659-3084
dc.description.abstractThe purpose of this study was to examine the effects bosentan (which is a strong vasoconstrictor) on bone fracture pathophysiology, and investigate the roles of the nonselective endothelin 1 receptor blocker bosentan on the bone fractures formed in rats through radiographic, histopathologic, and immunohistochemical methods. The rats were divided into three groups (six rats in each group): a femoral fracture control group, a femoral fracture plus bosentan at 50 mg/kg group, and a femoral fracture plus bosentan at 100 mg/kg group. The femoral fracture model was established by transversely cutting the femur at the midsection. After manual reduction, the fractured femur was fixed with intramedullary Kirschner wires. The radiographic healing scores of the bosentan 100 and 50 mg/kg groups were significantly better that those of the fracture control group. The fracture callus percent of new bone in the bosentan 100 mg/kg group was significantly greater than that in the control group. Also, semiquantitative analysis showed higher positive vascular endothelial growth factor and osteocalcin staining and lower positive endothelin receptor type A staining in the treatment groups than in the control group. Bosentan treatment also decreased tissue endothelin 1 expression relative to that in the fracture control group. As a result of our study, the protective effect of bosentan was shown in experimental femoral fracture healing in rats by radiographic, histopathologic, and molecular analyses.en_US
dc.description.sponsorshipAtaturk University Medical Research CouncilAtaturk University [2012/03]en_US
dc.description.sponsorshipWe thank Marc Iglarz and Actelion Pharmaceuticals Ltd for providing us with bosentan. This work was supported by the Ataturk University Medical Research Council (grant number 2012/03).en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1007/s00774-014-0622-6
dc.identifier.endpage506en_US
dc.identifier.issn0914-8779
dc.identifier.issn1435-5604
dc.identifier.issue5en_US
dc.identifier.pmid25298328
dc.identifier.scopus2-s2.0-84940789354
dc.identifier.scopusqualityQ1
dc.identifier.startpage496en_US
dc.identifier.urihttps://doi.org/10.1007/s00774-014-0622-6
dc.identifier.urihttps://hdl.handle.net/20.500.12587/6092
dc.identifier.volume33en_US
dc.identifier.wosWOS:000360706700004
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringer Japan Kken_US
dc.relation.ispartofJournal Of Bone And Mineral Metabolism
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBosentanen_US
dc.subjectEndothelin 1en_US
dc.subjectBone fractureen_US
dc.subjectRaten_US
dc.subjectFemuren_US
dc.titleWhat is the role of bosentan in healing of femur fractures in a rat model?en_US
dc.typeArticle

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