The red blood cell deformability alterations under desfluran anesthesia in rats

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dc.contributor.authorYerer, Mükerrem Betül
dc.contributor.authorAydogan, Sami
dc.contributor.authorÇomu, Faruk Metin
dc.contributor.authorArsland, Mustafa
dc.contributor.authorGüneş-Ekinci, Işın
dc.contributor.authorKurtipek, Ömer
dc.contributor.authorÜnal, Yusuf
dc.date.accessioned2020-06-25T17:41:09Z
dc.date.available2020-06-25T17:41:09Z
dc.date.issued2006
dc.departmentKırıkkale Üniversitesi
dc.description13th Conference of the European-Society-for-Clinical-Hemorheology -- JUN 26-29, 2005 -- Siena, ITALY
dc.descriptionYerer, Mukerrem B/0000-0002-4503-8032
dc.description.abstractGeneral anesthesia, either with inhalation or through nonvolatile anesthetics, is known to affect the overall cardiovascular function as well as the microcirculatory hemodynamics. In this study, the effects of desfluran anesthesia on the red blood cell deformability of young and old rats are investigated. 33 male rats were used in the study and the rats were divided into two groups according to their age (young and old) comprising of two subgroups in each. First group was the young control (n=5), the second was the young group treated with desfluran (n=7), the third group was the old control (n=7) and the last group was the old group treated with desfluran (n=7). %6 of desfluran was applied to the rats with inhalation in an adjustable cage for one hour. The elongation indexes of the erythrocytes were measured by a laser diffractometer (Myrenne Rheodyne SSD). Deformability indexes of red blood cells were significantly increased with desfluran in young rats (p=0.042) whereas they were significantly decreased in old rats (p=0.004) with desfluran application compared with their controls. When we compared the young and old control groups, the deformability indexes were significantly higher in old ones (p < 0.001). However, there was no significant difference between the old and the young desfluran applied groups. The volatile anesthetic agent desfluran impairs the deformability of erythrocytes in old rats compared to their controls, whereas it has the opposite effects on young ones. This may be due to the alterations in membrane structure with age. These results reveal that the inhalation of anesthetics like desfluran may cause more serious problems in the elder people during the surgery and may influence their hemodynamic parameters.en_US
dc.description.sponsorshipEuropean Soc Clin Hemorheolen_US
dc.identifier.citationclosedAccessen_US
dc.identifier.endpage216en_US
dc.identifier.issn1386-0291
dc.identifier.issue1-2en_US
dc.identifier.pmid16899930
dc.identifier.scopus2-s2.0-33746446293
dc.identifier.scopusqualityQ2
dc.identifier.startpage213en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12587/3643
dc.identifier.volume35en_US
dc.identifier.wosWOS:000239211300032
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherIos Pressen_US
dc.relation.ispartofClinical Hemorheology And Microcirculation
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectdesfluraneen_US
dc.subjecterythrocyte deformabilityen_US
dc.subjectanesthesiaen_US
dc.subjectraten_US
dc.titleThe red blood cell deformability alterations under desfluran anesthesia in ratsen_US
dc.typeArticle

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