Lactobacillus plantarum improves lipogenesis and IRS-1/AKT/eNOS signalling pathway in the liver of high-fructose-fed rats

Basit Öğe Kaydı
dc.contributor.authorSumlu, Esra
dc.contributor.authorBostanci, Aykut
dc.contributor.authorSadi, Gokhan
dc.contributor.authorAlcigir, Mehmet Eray
dc.contributor.authorAkar, Fatma
dc.date.accessioned2021-01-14T18:10:51Z
dc.date.available2021-01-14T18:10:51Z
dc.date.issued2020
dc.departmentKKÜ
dc.descriptionBostanci, Aykut/0000-0002-6855-0645; Sumlu, Esra/0000-0002-5004-5958; Sadi, Gokhan/0000-0002-6422-1203
dc.description.abstractIn the present study, we investigated the influence of Lactobacillus plantarum and Lactobacillus helveticus supplementation on lipogenesis, insulin signalling and glucose transporters in liver of high-fructose-fed rats. Fructose was given to the rats as a 20% solution in drinking water for 15 weeks. Lactobacillus plantarum and L. helveticus supplementations were performed by gastric gavage once a day during final 6 weeks. Dietary high-fructose increased hepatic weight, lipid accumulation and FASN expression as well as caused a significant reduction in IRS-1 expression, pAKT/total AKT and peNOS/total eNOS ratios, but an elevation in GLUT2 and GLUT5 mRNAs in the liver. Lactobacillus plantarum supplementation decreased hepatic weight, triglyceride content and FASN expression as well as improved IRS-1/AKT/eNOS pathway and GLUT2 expression in the liver of high-fructose-fed rats. However, L. helveticus supplementation exerted a restoring effect on lipid accumulation by decreasing FASN expression, and regulating effect on IRS-1 and GLUT2 expressions.en_US
dc.description.sponsorshipGazi University Research FundGazi University [02/2018-14]en_US
dc.description.sponsorshipThis study was supported by grants from the Gazi University Research Fund under Grant [02/2018-14].en_US
dc.identifier.citationBu makale açık erişimli değildir.en_US
dc.identifier.doi10.1080/13813455.2020.1727527
dc.identifier.issn1381-3455
dc.identifier.issn1744-4160
dc.identifier.pmid32067511
dc.identifier.scopus2-s2.0-85079701583
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1080/13813455.2020.1727527
dc.identifier.urihttps://hdl.handle.net/20.500.12587/12797
dc.identifier.wosWOS:000514727100001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTAYLOR & FRANCIS LTDen_US
dc.relation.ispartofARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDietary fructoseen_US
dc.subjectfatty liveren_US
dc.subjectinsulin signallingen_US
dc.subjectLactobacillus plantarumen_US
dc.subjectLactobacillus helveticusen_US
dc.titleLactobacillus plantarum improves lipogenesis and IRS-1/AKT/eNOS signalling pathway in the liver of high-fructose-fed ratsen_US
dc.typeArticle

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
[ X ]
İsim:
13813455.2020.pdf
Boyut:
2.59 MB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam metin/Full text
İndir

Koleksiyon

WOS İndeksli Yayınlar Koleksiyonu
Makale Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu