Relation of Kynurenine/Tryptophan with Immune and Inflammatory Markers in Coronary Artery Disease

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dc.contributor.authorOzkan, Yesim
dc.contributor.authorSukuroglu, Murat Kadir
dc.contributor.authorTulmac, Murat
dc.contributor.authorKisa, Ucler
dc.contributor.authorSimsek, Bolkan
dc.date.accessioned2020-06-25T18:12:25Z
dc.date.available2020-06-25T18:12:25Z
dc.date.issued2014
dc.departmentKırıkkale Üniversitesi
dc.descriptionKISA, Ucler/0000-0002-8131-6810; OZKAN, YESIM/0000-0002-1669-4962
dc.description.abstractBackground: Inflammation and immune activation have a crucial role in the pathogenesis of cardiovascular diseases. Indolamine 2,3-dioxygenase, a tryptophan catabolising enzyme, is up-regulated with various inflammatory stimuli. The aim of this study was to evaluate the relationship of tryptophan degradation with immune and inflammatory markers in coronary artery disease. Methods: 57 subjects undergoing coronary angiography were recruited. 18 subjects with normal coronary arteries according to Gensini scoring were selected as a control group and the rest of subjects were included in patient group. Serum tryptophan and kynurenine levels were determined with HPLC-UV method, and kynurenine/tryptophan ratio was evaluated as IDO activity. Serum neopterin and myeloperoxidase activity were measured by ELISA method. Results: While the kynurenine/tryptophan ratio and neopterin levels were similar in both groups, the patient group had higher myeloperoxidase and hs-CRP levels than controls (p = 0.02, p = 0.002, respectively). The kynurenine/tryptophan ratio was correlated with neopterin in both groups (r = 0.389, p = 0.025; r = 0.683, p = 0.002, respectively) and with hs-CRP in patients (r = 0.637, p = 0.001). Also, neopterin levels were correlated with hs-CRP in patients (r = 0.755, p = 0.0001). Conclusions: Our results are in line with a role of inflammation in coronary artery disease. The study provides evidence that IDO activity is related with immune and inflammatory states. Also, the study was performed in a limited hospital-based population. Further studies are warranted in the larger groups.en_US
dc.description.sponsorshipGazi University Research FundGazi University [02/2010-19]en_US
dc.description.sponsorshipThis study was supported by the Gazi University Research Fund (Project No: 02/2010-19).en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.7754/Clin.Lab.2013.121204
dc.identifier.endpage396en_US
dc.identifier.issn1433-6510
dc.identifier.issue3en_US
dc.identifier.pmid24697114
dc.identifier.scopus2-s2.0-84896474886
dc.identifier.scopusqualityQ3
dc.identifier.startpage391en_US
dc.identifier.urihttps://doi.org/10.7754/Clin.Lab.2013.121204
dc.identifier.urihttps://hdl.handle.net/20.500.12587/5907
dc.identifier.volume60en_US
dc.identifier.wosWOS:000342857300006
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherClin Lab Publen_US
dc.relation.ispartofClinical Laboratory
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectatherosclerosisen_US
dc.subjectindolamine 2,3-dioxygenaseen_US
dc.subjectkynurenineen_US
dc.subjectneopterinen_US
dc.subjecttryptophanen_US
dc.titleRelation of Kynurenine/Tryptophan with Immune and Inflammatory Markers in Coronary Artery Diseaseen_US
dc.typeArticle

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